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Showing 1-20 of 41 trials
NCT07540858
In this study, we investigated the impact of a comprehensive microgreen and wheatgrass juice protocol on the miRNA response following a standardized EIMD model and whether microgreen consumption could modulate key miRNA markers of neuromuscular regeneration and metabolic adaptation, thereby offering a novel nutritional approach to enhancing holistic recovery in athletes.
NCT06247774
The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise. The main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program. The trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study: * Cardiopulmonary exercise test (CPET) * Echocardiogram * Physical function test * 6-minute walk test * Hand grip strength * Quality of life questionnaire * Blood draws Researchers will compare results between those who do and don't participate in the exercise program.
NCT07445035
This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged mechanical ventilation admitted to a Respiratory Care Center. The goal is to provide clinical evidence for integrating rehabilitation and respiratory care in this patient population.
NCT07449663
This study examines how sport-specific high-intensity interval training (HIIT) affects the body in elite kickboxers. Participants are randomly assigned to either a HIIT training group or a control group. The HIIT group performs supervised sport-specific training for eight weeks, while the control group continues their usual training. Blood samples are collected before and after the training period. The main goal of this study is to determine whether HIIT changes levels of exercise-related proteins such as apelin and irisin. These proteins may reflect how the body adapts to intense training. The findings may help researchers and coaches better understand the effects of high-intensity training and may support the development of safer and more effective training programs for athletes.
NCT07432035
The goal of this study is to compare changes in walking ability in people with Charcot-Marie-Tooth disease (CMT) who receive two different treatment approaches for foot deformities that affect walking. CMT is an inherited nerve condition that can cause muscle weakness, loss of sensation, and foot deformities. These changes often make walking difficult and can reduce independence and quality of life. Treatment options commonly include physical therapy alone or surgery to correct foot alignment followed by rehabilitation. However, it is not clear whether one approach leads to better long-term walking outcomes. The main question this study aims to answer is whether individuals who undergo functional foot surgery followed by rehabilitation experience different changes in walking ability over time compared with those who receive structured physical therapy alone. Researchers will compare walking performance between these two treatment groups over a period of up to two years. Walking ability will be evaluated using standardized walking tests and patient questionnaires. Participants included in this study are individuals with CMT-related foot deformities that affect walking and who received either surgery followed by rehabilitation or physical therapy alone. Researchers will analyze changes in walking ability over time and determine how many participants achieve meaningful improvement. The findings from this study may help clinicians and individuals with CMT better understand how different treatment strategies influence walking function over time.
NCT07421986
Here is the complete Brief Summary entry in a single paragraph, written in plain language, and excluding the study results (as requested), but maintaining academic rigor in describing the study design: The purpose of this study is to evaluate the effect of a 4-week short-term eccentric strengthening program using elastic bands on both hip adductor muscle strength and agility performance in young male basketball players. For this randomized controlled trial, twenty-one healthy young male athletes were separated by chance into two conditions: a training group, which performed the 4-week elastic band protocol in addition to their regular basketball training, and a control group, which engaged exclusively in their routine training. The primary measurements for comparison were maximal eccentric and isometric hip adduction strength (using a hand-held dynamometer) and the agility T-test. It is hypothesized that this targeted eccentric strengthening will lead to a significant enhancement of both hip adduction strength and overall athletic performance in the intervention group
NCT07399119
Researchers will split the sixty healthy smokers in half. Thirty people will serve as a control group and will be asked to walk or jog at a controlled pace for twelve minutes as part of an aerobic exercise program. Separately, 30 people participated in an aerobic exercise session that lasted 12 minutes and involved walking or running at a pace that the participants themselves controlled. WHBM will be done both prior to and subsequent to physical activity. To determine how WHBM affects the experimental group's pre- and post-WHBM heart rates, SpO2, blood pressure, and VO2 max, this study will be conducted.
NCT07137611
Purpose The purpose of this study is to determine the acute effects of different exercise intensities (low, moderate, high) on brain-derived neurotrophic factor (BDNF) levels, trail making test performance, and perceived sensation scale. Method This randomized crossover controlled trial aimes to examine the acute effects of four experimental conditions-high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), low-intensity continuous training (LICT), and a resting control (CTRL)-on cognitive performance (via the Stroop test, targeting executive function) and associated neurochemical responses (e.g., serum BDNF and blood lactate levels) in healthy young adults aged 18-25 years. All participants will complete the four conditions in a randomized and counterbalanced manner. To ensure balanced exposure, they were assigned to one of four groups (n = 3 per group), each following a distinct condition order based on a Latin square design. This approach guaranteed that each session occurred equally across time points (sessions 1-4) and that the order minimized sequence effects by rotating the position of each condition relative to the others. To control for potential carryover-particularly from elevated neurochemical responses following intense exercise (BDNF increases reported -no two high-intensity sessions will be scheduled consecutively. Where possible, higher and lower intensity protocols will be alternated. Furthermore, a seven-day interval separated each session to reduce residual physiological or cognitive effects. The trial protocol was developed in line with CONSORT and SPIRIT guidelines, including relevant extensions for within-subject designs and non-pharmacological interventions. Participants were blinded to the study hypothesis (Pandis et al., 2017; Hopewell et al., 2025). All exercise sessions will be conducted under supervision of a certified strength and conditioning coach to ensure consistency and adherence to protocol. in the morning (09:00-11:00) on a track and field pitch to control for chronobiological variation. Participants were instructed to avoid strenuous activity for 48 hours prior, abstain from alcohol and caffeine for 24 hours, and obtain at least 7-8 hours of sleep before each session. Dietary habits and general lifestyle were to remain unchanged throughout the study. During the first visit, participants' body weight and body fat percentage were assessed using bioelectrical impedance analysis. Resting heart rate was then recorded, followed by administration of the Yo-Yo Intermittent Recovery Test Level 1 to determine maximal aerobic speed, aerobic capacity, and peak heart rate. In the following four visits, each participant completed all experimental conditions. Each exercise session will begin with a standardized 10-minute warm-up, including light jogging, dynamic stretching, and movement preparation drills. All exercise sessions were conducted on a standard track and field facility and lasted 40 minutes in total, consisting of a 10-minute standardized warm-up, 24 minutes of exercise, and a 5-minute recovery period. The exercise component was individually prescribed based on each participant's maximal aerobic speed, determined from the Yo-Yo Intermittent Recovery Test Level 1. All running distances were calculated individually using time × speed formulas based on each participant's maximal aerobic speed, ensuring workload equivalence across conditions. * High-Intensity Interval Training: Participants ran at 110% of their MAS for 15-second intervals. * Moderate-Intensity Continuous Training: Participants ran at a speed corresponding to 70-80% of their MAS. * Low-Intensity Continuous Training: Participants ran continuously for 24 minutes at 50-60% of their MAS without breaks. * Control: Participants remained seated at rest for the same duration (40 minutes), under the same environmental conditions and time schedule as the active conditions. Venous blood samples were collected before and immediately after each session to assess neurochemical markers. Subsequently, cognitive performance was evaluated using the computerized Stroop test to measure executive function. Heart rate was continuously monitored during all exercise conditions using a Polar V800 device. Following each session, psychophysiological responses were assessed using the Rating of Perceived Exertion scale and the Exercise Enjoyment Scale.
NCT07264751
The study aims to assess the acute response of wrestlers to a single training session. Short-term changes in inflammatory, hormonal, and metabolic markers will be analyzed, which may reflect the development of fatigue and recovery processes following intense exercise. Participation in the study involves performing a standard training session and collecting blood samples at three time points to assess the physiological response. The results will provide a better understanding of the mechanisms of adaptation to exercise in strength and endurance athletes.
NCT07128030
The aim of this study was to evaluate the feasibility, safety, and acceptability of a supervised, combined moderate-intensity aerobic and resistance training program designed to reduce pain sensitization in BCS with persistent pain. Secondary objectives included assessing changes in pain intensity, somatosensory sensitivity, and temporal summation, while tertiary objectives focused on improvements in quality of life and functional capacity.
NCT06453473
The Israeli research group of this trial has developed the Perturbation Stationary Bicycle Robotics (PerStBiRo) system that can challenge balance while sitting. With this system, unexpected perturbations can be provided under controlled and safe conditions. Within the BiPerAge-project it will be evaluated if 20 training sessions (20 minutes each) on the PerStBiRo system will lead to transfer effects on safe cycling skills of community-dwelling older adults (age 65 years and older). The ability to cycle safely will be tested prior and after the training period using a cycling course, which consists of variant tasks requiring motor and cognitive skills.
NCT07093190
The goal of this interventional study is to observe the effects of bone marrow stem cell behavior in skeletal muscle of women between 60 to 75 years old after a single moderate resistance exercise session. Plant sterol Rg1, a compound known to enhance stem cell infiltration following exercise in young men will be tested against a placebo in a double blinded crossover design. The main questions to be answered are: * Does Rg1 supplementation alter serum sex hormone levels in recovery from exercise? * Does Rg1 supplementation influence bone marrow stem cell differentiation in skeletal muscles of older women? Participants will: * Pre-test body composition, maximal leg strength, blood and muscle tissue. * One hour after taking the supplement, participants will perform 4 sets of 10 repetitions of 70% of maximal strength (1RM) leg press and have two thigh muscle biopsies (0 and 24 h after exercise). * Repeat the protocol one month later on the alternative supplement. Researchers will understand whether Rg1 improves recovery response to resistance exercise in post-menopausal women.
NCT07042750
Eccentric cycling exercise (ECC) allows training at low metabolic costs and may therefore be valuable for patients with pulmonary vascular disease (PVD). For these patients, regular exercise training has an evidence level 1A recommendation in the current guidelines. Exercise training during longer and regular periods provides chronic adaptation, for which ECC was recently found to have a greater effectiveness than CON by increasing muscle strength, hypertrophy, six-minute walking distance and furthermore, by increasing maximum oxygen uptake (V'O2max) especially in patients with chronic obstructive pulmonary disease (COPD), chronic left heart failure or coronary heart disease. Furthermore, we conducted an RCT in which we exposed patients with PVD to ECC and concluded that ECC is a feasible and well-tolerated exercise modality for PVD patients with severely lower O2 demand and load to the right ventricle. The study in patients with PVD was started (EccRehab), and the great potential was recognized. Therefore there was an indication to open the inclusion criteria to all cardiopulmonary patients with indication for pulmonary rehabilitation (EccRehab2). For this purpose, the aim of this project is to investigate whether ECC improves exercise capacity and possibly hemodynamics during prolonged rehabilitation programs in patients with cardiopulmonary diseases.
NCT06123182
The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out. Participants will be asked to complete testing at the beginning of the study, following 6-weeks of an in-person exercise program, and 6-weeks after finishing the exercise program. Testing will include an exercise test, MRI, questionnaires, computer tasks, and a blood draw.
NCT06610955
Obesity is one of the most common preventable public health problems. Diet regulation and exercise practices are the most commonly used methods in reducing fat tissue. There are various exercise methods applied in the weight loss process and the effects of different types of exercise modalities on body fat rate and metabolic status.The aim of our study is to determine the effects of high intensity interval exercise and moderate intensity continuous exercise on serum , omentin, leptin and adiponectin levels, anthropometric measurements used in obesity follow up, body fat percentage and their effects on the quality of sleep and life of women with obesity.
NCT06419452
This study is to explore the effects of unilateral, bilateral and combined resistance training on the serve speed and accuracy of amateur youth tennis players in China. The subjects were young male tennis players aged 16-20 years from four universities in Gansu Province. The experiment was divided into control group (CG), experiment group 1 (EG1-unilateral group), experiment group 2 (EG2-bilateral group) and experiment group 3 (EG3-combined group). Used to compare the effects of different forms of resistance training on serve speed and accuracy. Previous studies have shown that unilateral and bilateral resistance training can effectively improve strength, power, and speed in athletes (Speirs, et al., 2016; Davo, Jimenez, \& Solana,. , 2018), there is still controversy when comparing the advantages and disadvantages of two forms of resistance training (Ramirez-Campillo et al., 2015; Donab and Wall. The results of this study will be expected to be updated in 2022. Unilateral resistance training, bilateral resistance training, and combined unilateral and bilateral resistance training were used as intervention models in this study. Based on the literature review, the training frequency of this experiment was arranged as 2 times/week, and the total training time was 6 weeks, with a fixed duration of each training session. Each training session lasted a maximum of 60 minutes. In this experiment, the interval between the two weekly training sessions was at least 24 h to prevent subjects from being in a fatigued state in the relevant muscle groups of the body and affecting the experimental level.
NCT05485506
This study is designed to evaluate the effects of a multimodal exercise program in the sprint performance and kinematics of adolescent rugby players. For this, an experimental study with an intervention group (IG) and a control group (CG) is designed. During 6 weeks of the 2022-2023 preseason of rugby seven, IG will include a multimodal exercise program in their training routine. Meanwhile, CG will maintain their training routine. The study will be developed in the Sport High Performance Centre of Balearic Islands during the season of rugby seven (from August to September, 2022). All rugby athletes from under-16 and under-18 autonomic rugby teams will be invited to participate in this study throughout an email invitation from their regional rugby federation. Prior to the beginning of the study, all participants will sign the inform consent, or their legal tutors in case of minors. The Ethical Committee of the local university approved this study (278CER22) according to the Declaration of Helsinki. One week before intervention period, sociodemographic and sportive data will be registered (age, sex, body mass, height, and sport experience). Body mass and height will be evaluated with a ±100-g precision digital weight scale (Tefal, France) and a t201-t4 adult height scale (Asimed, Spain), respectively. Also, the rugby players will complete a familiarization process consisting on a standardized warm up and 3 progressive sprints (i.e. 30 m at 50%, 70% and 90% of maximal effort). All testing procedure (pre-test and post-test) will be completed at a similar daytime (between 17h and 19h) on the same natural grass field. The test procedure listed in our study will consist on two maximal 30-m sprints to obtain mechanical variables of horizontal force-velocity profile and kinematics during sprinting. Players from IG will perform a multimodal exercise program two days per week during six weeks. This program will include running technical drills, exercises for lumbopelvic stabilization and resisted sprints. This program will be supervised by two experts in this field. The investigators hypothesize that those rugby players who add the multimodal exercise program to their training routine will increase mechanical and kinematics variables of sprint performance.
NCT05763394
Recent studies have shown that polarized training (i.e. the combination in the same session of intermittent high intensity exercise training, consisting of repeated, short-duration, high-intensity exercises on a cycle ergometer or a treadmill, and moderate exercise) can encourage the participation of obese people in body weight reduction programs, providing more dynamic exercises, less tiring and therefore more acceptable. To date, no data are available on the effects of polarized exercise in the rehabilitation of obese adolescents, who are often unwilling to engage in prolonged and monotonous motor activities. The demonstration that the polarized exercise might encourage the participation of obese adolescents in multidisciplinary body weight reduction programs, improve the cardiovascular capacity and also favor an adequate oxidation of lipids during the phase of exercise and post-exercise rest, could support its prescription in the programs of integrated metabolic rehabilitation of adolescent obesity.
NCT06575985
This study will consist of a parallel-groups design, with 30 healthy active female participants randomly assigned to either an experimental heat acclimation and exercise intervention, or a thermo-neutral exercise intervention control group. Interventions will be 10 days in duration, and consist of daily 60-minute exercise bouts under the appropriate environmental condition. Before and after each intervention, various tests will be conducted to establish exercise capacity under various environmental conditions, as well as underlying mechanisms of physiological adaptation induced by each intervention.
NCT06409793
The researchers are investigating whether adding mobile technology to a home-based exercise counselling program makes it easier for youth to begin and maintain regular exercise. Participants who joins the study will receive exercise counselling from an exercise specialist, but half of all participants will receive mobile technology - a fitness watch - that links to a mobile phone App. The mobile App allows the exercise specialist to provide personalized feedback throughout the program via the fitness watch. The investigators are interested to know whether the fitness watch and mobile App will make it easier for youth to achieve their exercise goals. Both groups will be compared to an active control group, who will receive no exercise program.