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Clinical Trials in Tennessee | 20,239 Studies Near You | Clareo Health

Clinical Trials LocationsTennessee

Clinical Trials in Tennessee

Discover 20,239 clinical trials near Tennessee. Find research studies in your area.

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Showing 4321-4340 of 20,239 trials

COMPLETEDPhase 218 miles

A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Acne Vulgaris

NCT04856917

Efficacy and Safety of Imsidolimab in Participants with Acne Vulgaris

Vanda Pharmaceuticals123 participantsStarted May 2021

Hot Springs, Arkansas, United States • Fountain Valley, California, United States • Sherman Oaks, California, United States +12 more locations

COMPLETEDPhase 1/229 miles

CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma

NCT03425279

The objective of this study is to assess the safety and efficacy of mecbotamab vedotin (BA3011) in solid tumors.

Undifferentiated Pleomorphic SarcomaMyxofibrosarcoma

BioAtla, Inc.245 participantsStarted Feb 2018

Tucson, Arizona, United States • Los Angeles, California, United States • Los Angeles, California, United States +37 more locations

Find Trials by Condition in Tennessee

Breast Cancerin Tennessee Lung Cancerin Tennessee Prostate Cancerin Tennessee Colorectal Cancerin Tennessee Melanomain Tennessee Leukemiain Tennessee Lymphomain Tennessee Pancreatic Cancerin Tennessee Ovarian Cancerin Tennessee Brain Cancerin Tennessee

Data from ClinicalTrials.govTerms

TERMINATEDPhase 129 miles

A Study of STRO-002, an Anti-Folate Receptor Alpha Antibody Drug Conjugate, in Combination With Bevacizumab in Epithelial Ovarian Cancer

NCT05200364

Phase 1 trial to study the safety, pharmacokinetic and Preliminary Efficacy of STRO-002 in combination with Bevacizumab.

Ovarian CancerOvarian CarcinomaOvary Cancer+2 more

Sutro Biopharma, Inc.58 participantsStarted Mar 2022

Tampa, Florida, United States • Philadelphia, Pennsylvania, United States • Philadelphia, Pennsylvania, United States +3 more locations

COMPLETEDPhase 2154 miles

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

NCT02070744

The objective of this study was to evaluate the safety and efficacy of VX-661in combination with ivacaftor in participants with cystic fibrosis (CF) who are homozygous for F508del cystic fibrosis transmembrane conductance regulator (CFTR) mutation

Cystic Fibrosis

Vertex Pharmaceuticals Incorporated40 participantsStarted Mar 2014

Birmingham, Alabama, United States • Palo Alto, California, United States • Stanford, California, United States +20 more locations

Active Not RecruitingPhase 2154 miles

Phase 2 Safety and Efficacy Evaluation of AL8326 in ≥2nd Line SCLC

NCT05363280

This trial is a Phase II trial designed to evaluate the safety and efficacy of using oral AL8326 , a multi-targeted receptor Tyrosine Kinase Inhibitor( TKI) , to recurrent, advanced, or metastatic small cell lung cancer (SCLC) patients who need ≥2nd line treatment .

Small Cell Lung Cancer

Advenchen Pharmaceuticals, LLC.36 participantsStarted Nov 2022

Birmingham, Alabama, United States • Chicago, Illinois, United States • St Louis, Missouri, United States +3 more locations

Not Yet RecruitingNA154 miles

Weight Bearing After Pelvis and Acetabulum Fracture Fixation

NCT07189156

The goal of this study to determine if a randomized clinical trial of immediate versus delayed weight bearing after undergoing surgical fixation of a pelvis or acetabulum fracture is feasible. The main questions it aims to answer are: Are surgeons willing to allow inclusion of their patients into such a trial? Are patients willing to participate in such a trial? Will patients be compliant with assigned weight bearing status in such a trial? Can good patient follow-up be obtained in such a trial? Is participation in such a trial safe? Patients from 7 medical centers will be enrolled, and randomized to immediate weight bearing as tolerated (WBAT) versus delayed WBAT (for 6-12 weeks). Feasibility metrics revolving around enrollment, follow-up, and documentation will be monitored, as well as medical and surgical complications. This pilot study will help inform feasibility and design of a larger definitive multicenter randomized controlled trial (RCT) on this topic.

Pelvis FracturesAcetabulum Fractures

University of Mississippi Medical Center200 participantsStarted Oct 2025

Birmingham, Alabama, United States • Colton, California, United States • Indianapolis, Indiana, United States +4 more locations

Active Not RecruitingPhase 2154 miles

Study of Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) in Prevention of HIV in Cisgender Women in the United States (HPTN 102)

NCT06101329

The goal of this clinical study is to look at how lenacapavir (LEN) passes through the body and to assess the safety of LEN and emtricitabine/tenofovir disoproxil fumarate (F/TDF) for prevention of HIV in the cisgender women in the US. The primary objectives of this study are: 1) to characterize the pharmacokinetics (PK) of LEN in United States (US) cisgender women; 2) to evaluate the safety of LEN and F/TDF for pre-exposure prophylaxis (PrEP) in US cisgender women; and 3) to evaluate the general acceptability of LEN injections and oral F/TDF in US cisgender women.

Pre-Exposure Prophylaxis of HIV Infection

Gilead Sciences253 participantsStarted Nov 2023

Birmingham, Alabama, United States • San Diego, California, United States • Washington D.C., District of Columbia, United States +8 more locations

COMPLETEDPhase 3156 miles

A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

NCT06045221

The main purpose of this study is to assess efficacy and safety of orforglipron compared with oral semaglutide in participants with Type 2 diabetes and inadequate glycemic control with metformin.The study will last around 61 weeks.

Type 2 Diabetes

Eli Lilly and Company1,698 participantsStarted Sep 2023

Phoenix, Arizona, United States • Canoga Park, California, United States • Escondido, California, United States +128 more locations

COMPLETEDNA178 miles

Investigational Extended Wear Insulin Infusion Set in People With Type 1 Diabetes

NCT06273124

The purpose of this study is to collect clinical data to support a 7-day wear of the Extended Wear Infusion Set (EWIS). Participants will be asked to: 1. Wear the EWIS for up to 7 consecutive days for 12 consecutive wear periods 2. Perform blood glucose and ketone measurements if continuous glucose meter is ≥250mg/dL for one hour

Tandem Diabetes Care, Inc.260 participantsStarted Mar 2024

Newport Beach, California, United States • Stanford, California, United States • Aurora, Colorado, United States +12 more locations

Active Not RecruitingPhase 4190 miles

A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

NCT06112743

The purpose of this study is to evaluate the mavacamten impact on myocardial structure with cardiac magnetic resonance imaging (CMR) in adult participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) \[New York Heart Association (NYHA) Functional Class II or III\].

Cardiomyopathy, Hypertrophic

Bristol-Myers Squibb63 participantsStarted Jan 2024

West Hollywood, California, United States • Atlanta, Georgia, United States • Boston, Massachusetts, United States +20 more locations

COMPLETEDPhase 2277 miles

Evaluate the Safety, Efficacy, and Pharmacokinetics of CRN04894 in Participants With Congenital Adrenal Hyperplasia (TouCAHn)

NCT05907291

The purpose of this Phase 2, open-label, sequential dose cohort study is to evaluate the safety, efficacy, and pharmacokinetics (PK) of atumelnant (CRN04894) in participants with classic congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency.

Congenital Adrenal HyperplasiaClassic Congenital Adrenal Hyperplasia

Crinetics Pharmaceuticals Inc.38 participantsStarted Jul 2023

Pasadena, California, United States • Ann Arbor, Michigan, United States • Minneapolis, Minnesota, United States +24 more locations

RECRUITINGNA425 miles

Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial

NCT04883671

The aim of this study is to learn whether the early initiation of a specialized and focused type of radiation called stereotactic body radiation therapy (SBRT) will impact the progression of advanced adenoid cystic carcinoma, quality of life, and overall survival. The name(s) of the study intervention involved in this study is: * Stereotactic Body Radiation Therapy (SBRT)

Adenoid Cystic CarcinomaMetastatic Adenoid Cystic Carcinoma

Dana-Farber Cancer Institute32 participantsStarted Dec 2021

San Francisco, California, United States • Chicago, Illinois, United States • Boston, Massachusetts, United States +2 more locations

Active Not RecruitingPhase 2434 miles

4D-150 in Patients With Diabetic Macular Edema

NCT05930561

Phase 2 randomized, active-controlled, double-masked, dose-ranging trial in adults with Diabetic Macular Edema (DME).

Diabetic Macular EdemaDiabetic Retinopathy

4D Molecular Therapeutics72 participantsStarted Aug 2023

Hagerstown, Maryland, United States • Eugene, Oregon, United States • Erie, Pennsylvania, United States +3 more locations

Active Not RecruitingEARLY Phase 1437 miles

Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)

NCT05634707

The purpose of this research study is to determine if fluoxetine increases lysosomal stress in patients with recurrent IDHwt glioma by evaluating LAMP1 expression in tumor samples obtained pre-resection via biopsy and during surgery. Lysosomes are organelles (structures in cells) that contain digestive enzymes (substances that break down chemicals) that help keep the cells free of extra or worn out cell parts. Fluoxetine, a drug approved by the FDA to treat problems like depression and anxiety, can cause changes to structures in cells called lysosomes that then improve how well the chemotherapy drug temozolomide (TMZ) kills cancer cells in the brain.

Primary Brain TumorBrain Tumor, Recurrent

Duke University10 participantsStarted Aug 2023

San Diego, California, United States • Stanford, California, United States • New York, New York, United States +1 more locations

COMPLETEDPhase 1449 miles

A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943

NCT06313528

The main purpose of the study is to look at the effect of the study drug compared to placebo on calorie intake, energy metabolism, and appetite. The study will last up to 6 months and may include up to 20 visits.

Eli Lilly and Company85 participantsStarted Mar 2024

Orlando, Florida, United States • Baton Rouge, Louisiana, United States • New York, New York, United States

Active Not RecruitingPhase 1452 miles

A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation

NCT05485974

A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recommended Phase II dose of HBI-2438 and characterize its pharmacokinetic profile.

Lung CancerNon Small Cell Lung CancerColorectal Cancer+4 more

HUYABIO International, LLC.44 participantsStarted Aug 2022

Encinitas, California, United States • Glendale, California, United States • Long Beach, California, United States +11 more locations

RECRUITINGPhase 1553 miles

R-2487 in Patients With Rheumatoid Arthritis

NCT05961592

The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-2487) in patients with Rheumatoid Arthritis. Patients will take an oral dosage of probiotic (R-2487) and physicians will assess and measure their Rheumatoid Arthritis. Blood and fecal evaluations of inflammation and assessment of probiotic (R-2487) on fecal level will also be measured.

Arthritis, Rheumatoid

Rise Therapeutics LLC73 participantsStarted Oct 2023

San Diego, California, United States • Doral, Florida, United States • Miami, Florida, United States +2 more locations

RECRUITINGNA559 miles

Beacon Sensors and Telerehabilitation to Assess and Improve Use of Devices (BeST-AID) for Low Vision

NCT06107881

One goal of this research is to conduct a non-inferiority trial of telerehabilitation versus in-office care to provide follow-up training to individuals with low vision to enhance their quality of life by using magnification devices and/or visual assistive mobile apps for important daily activities, such as reading and/or other valued tasks. This is a high priority given the increasing prevalence of low vision, paucity of low vision rehabilitation providers, and barriers related to access to care, such as transportation and geography, which can be essentially eliminated with telerehabilitation. Another goal of this project is to determine whether significant changes in environmental data collected by Bluetooth low energy beacon sensors can be used as a solution to monitor and indicate when low vision patients' have abandoned the use of their magnification devices, which has the potential to substantially enhance patient management by providing timely low vision rehabilitation services.

Low VisionLow Vision Aids

University of California, Los Angeles350 participantsStarted Dec 2023

Fullerton, California, United States • Grass Valley, California, United States • Los Angeles, California, United States +6 more locations

RECRUITINGPhase 2567 miles

An Extension Study to Evaluate Safety and Efficacy in Participants Treated With CRN04894

NCT06712823

The purpose of this study is to evaluate the long-term safety, tolerability, and efficacy of atumelnant (CRN04894).

Congenital Adrenal HyperplasiaClassic Congenital Adrenal Hyperplasia

Crinetics Pharmaceuticals Inc.150 participantsStarted Feb 2025

Minneapolis, Minnesota, United States • Morehead City, North Carolina, United States • Córdoba, Córdoba Province, Argentina +6 more locations

COMPLETEDPhase 31360 miles

A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF)

NCT04969224

This study will evaluate the effects of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on cough and physical activity using wearable technology in CF participants.

Cystic Fibrosis

Vertex Pharmaceuticals Incorporated82 participantsStarted Oct 2021

Adelaide, Australia • Chermside, Australia • Melbourne, VIC, Australia +16 more locations

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