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Incidence of Hematologic and Non-Hematologic Malignancies, Thrombotic Events, and Autoimmune Disorders in Unrelated Normal Donors Undergoing Bone Marrow Harvest Versus Peripheral Blood Stem Cell Mobilization With Recombinant Human Granulocyte Colony-Stimulating Factor (rHuG-CSF)
This is an observational study of unstimulated bone marrow (BM) and filgrastim-mobilized peripheral blood stem cell (PBSC) donors. The primary goal is to evaluate the hypothesis that the incidence of targeted malignant, thrombotic and autoimmune disorders after unrelated hematopoietic stem cell donation are similar between unstimulated BM and filgrastim-mobilized PBSC donors.
This is an observational study of unstimulated bone marrow (BM) and filgrastim-mobilized peripheral blood stem cell (PBSC) donors. The primary goal is to evaluate the hypothesis that the incidence of targeted malignant, thrombotic and autoimmune disorders after unrelated hematopoietic stem cell donation are similar between unstimulated BM and filgrastim-mobilized PBSC donors. Donors will undergo biennial surveys until study completion. Cases of targeted disorders will be reviewed by the medical monitors to confirm the veracity of the report.
Age
18 - 60 years
Sex
ALL
Healthy Volunteers
No
City of Hope
Duarte, California, United States
National Marrow Donor Program Northern California & Northwest District
Oakland, California, United States
National Marrow Donor Program Southern California & Southwest District
Santa Ana, California, United States
Colorado Marrow Donor Program
Denver, Colorado, United States
OneBlood
Fort Lauderdale, Florida, United States
Hawaii Bone Marrow Donor Registry
Honolulu, Hawaii, United States
LifeSource
Glenview, Illinois, United States
Rock River Valley Blood Center
Rockford, Illinois, United States
Indiana Blood Center
Indianapolis, Indiana, United States
National Marrow Donor Program Southcentral District, Heart of America
Leawood, Kansas, United States
Start Date
October 1, 2010
Primary Completion Date
September 30, 2020
Completion Date
October 15, 2020
Last Updated
October 20, 2020
21,974
ACTUAL participants
Lead Sponsor
Center for International Blood and Marrow Transplant Research
Collaborators
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT06339541