Clinical Trials in Pittsburgh

Showing 16841-16860 of 21,047 trials

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

NCT01173497

The purpose of the study is to investigate the response rate for triple negative breast cancer patients with brain metastasis when INIPARIB is used in combination with irinotecan. Based on data generated by BiPar/Sanofi, it is concluded that iniparib does not possess characteristics typical of the PARP inhibitor class. The exact mechanism has not yet been fully elucidated, however based on experiments on tumor cells performed in the laboratory, iniparib is a novel investigational anti-cancer agent that induces gamma-H2AX (a marker of DNA damage) in tumor cell lines, induces cell cycle arrest in the G2/M phase in tumor cell lines, and potentiates the cell cycle effects of DNA damaging modalities in tumor cell lines. Investigations into potential targets of iniparib and its metabolites are ongoing.

Estrogen Receptor Negative (ER-Negative) Breast CancerProgesterone Receptor Negative (PR-Negative) Breast CancerHuman Epidermal Growth Factor Receptor 2 Negative (HER2-Negative) Breast Cancer+1 more

Sanofi44 participantsStarted Jul 2010

Birmingham, Alabama, United States • San Francisco, California, United States • Washington D.C., District of Columbia, United States +10 more locations

COMPLETEDPhase 2< 1 mile

Safety and Efficacy of BKM120 in Patients With Metastatic Non-small Cell Lung Cancer

NCT01297491

The purpose of this two-stage phase II study is to assess the efficacy of BKM120, as measured by determining the progression free survival (PFS), in patients with pretreated metastatic Non-small Cell Lung Cancer (NSCLC) that exhibits PI3K pathway activation. BKM120 will be investigated in two groups of NSCLC patients according to the histology of the cancer: squamous and non-squamous.

Non-small Cell Lung Cancer

Novartis Pharmaceuticals63 participantsStarted May 2011

Chandler, Arizona, United States • Phoenix, Arizona, United States • Scottsdale, Arizona, United States +89 more locations

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

Safety and Efficacy of BKM120 in Patients With Metastatic Non-small Cell Lung Cancer

Find Trials by Condition in Pittsburgh

Ischemic Foot Ulcers: Is Intervention Better Than Wound Care Alone

Efficacy, Safety And Tolerability Study Of RN6G In Subjects With Geographic Atrophy Secondary to Age-related Macular Degeneration

Trial of Gemcitabine/Carboplatin With or Without Iniparib (SAR240550) (a PARP1 Inhibitor) in Subjects With Previously Untreated Stage IV Squamous Non-Small-Cell Lung Cancer (NSCLC)

A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia

Open Label Extension of Prior TERMS Study to Treat Relapsing Forms of Multiple Sclerosis

Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers

Evaluation of the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures

Safety and Efficacy Study of Ramelteon (TAK-375) Tablets for Sublingual Administration (SL) in Adults With Bipolar 1 Disorder

Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole

Study of Intravenous NRX-1074 in Patients With Major Depressive Disorder

An Observational Study on Long-Term Persistence of Resistant Mutations And Durability of Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Direct Acting Antiviral (DAA)- Containing Regimens

Lurasidone HCL - A 6-week Phase 3 Study of Patients With Acute Schizophrenia.

Randomized Trial of Suicide Gene Therapy and Prostate Cancer

Atacicept Phase 2/3 in Generalized Systemic Lupus Erythematosus (APRIL-SLE)

APT001 Plasma/NO Generator to Treat Diabetic Foot Ulcer in Adults

Elder Surgery - Functional Recovery Following Beta Blockade

A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal Renal Function

Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients