Clinical Trials in Pittsburgh

Showing 12601-12620 of 18,076 trials

Study of PX-866 and Vemurafenib in Patients With Advanced Melanoma

NCT01616199

The purpose of the phase 1 portion of the study is to determine the maximally tolerated dose (MTD) or recommended dose (RD) and the safety/tolerability of PX-866 in combination vemurafenib in patients with any advanced BRAF-mutant cancer. The purpose of the phase 2 portion of the study is to compare progression free survival (PFS), antitumor activity (response rate), disease control rate (DCR), and the safety and tolerability of PX-866 in combination with vemurafenib vs. vemurafenib alone in patients with advanced BRAF-mutant melanoma at the doses recommended from Phase 1.

Advanced BRAF-mutant Cancers

Cascadian Therapeutics Inc.24 participantsStarted Aug 2012

Tampa, Florida, United States • New York, New York, United States • Philadelphia, Pennsylvania, United States +2 more locations

COMPLETEDNA< 1 mile

Radiosurgery or Open Surgery for Epilepsy Trial

NCT00860145

This study will compare radiosurgery (focused radiation, Gamma Knife Radiosurgery) with temporal lobectomy (standard surgical care) as a treatment of temporal lobe epilepsy. Patients who have seizures that begin in their temporal lobe that are not controlled with medications into the trial will be offered entry. Patients with a high likelihood of having their seizures controlled with open surgery will have treatment randomized between the standard surgery and radiosurgery. A prior study has shown that focused radiation (radiosurgery) may also reduce or eliminate seizures arising from the temporal lobe. The main study hypothesis is that radiosurgery is as safe and effective as temporal lobectomy in treating patients with seizures arising from the medial temporal lobe.

Epilepsy

University of California, San Francisco61 participantsStarted Sep 2009

Birmingham, Alabama, United States • La Jolla, California, United States • Los Angeles, California, United States +11 more locations

Study of PX-866 and Vemurafenib in Patients With Advanced Melanoma

Radiosurgery or Open Surgery for Epilepsy Trial

Find Trials by Condition in Pittsburgh

A Study in Participants With Rheumatoid Arthritis

Usability of an AI for M923 in Subjects With Moderate to Severe RA

PF-00489791 For The Treatment Of Raynaud's

A Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma)

Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I

Study of Efficacy and Safety of Canakinumab in Patients With Hereditary Periodic Fevers

Biomarkers in Patients With Previously Untreated Invasive Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer

Vascular Inflammation in Psoriasis - Extension Study

Phase 1 and 2 Study of PX-866 and Cetuximab

Prospective Multicenter Registry On RadiaTion Dose Estimates Of Cardiac CT AngIOgraphy IN Daily Practice in 2017

Safety and Efficacy of NNC-0156-0000-0009 After Long-Term Exposure in Patients With Haemophilia B: An Extension to Trials NN7999-3747 and NN7999-3773

Phase 2 Study of a New Ophthalmic Formulation of Cyclosporine (Restasis® X) in Patients With Dry Eye Disease

A Study of the Safety and Pharmacokinetics of RO6839921, An MDM2 Antagonist, in Patients With Advanced Cancers, Including Acute Myeloid Leukemia.

A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor

Safety, Tolerability, PD & PK of Calcipotriene 0.005% Foam, Under Maximal Use in 12-16 Year Olds With Plaque Psoriasis

DFD06 Cream vs Clobetasol Propionate Cream, 0.05% Hypothalamic- Pituitary-Adrenal (HPA) Axis Suppression Study in Patients With Moderate to Severe Plaque Psoriasis

Gadobutrol/Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

The Impact of Vitamin D on Disease Activity in Crohn's Disease