Clinical Trials in Pittsburgh

Showing 11301-11320 of 17,577 trials

Role of NGS-based ThyroSeq Panel in Cancer Diagnosis in Thyroid Nodules

NCT02352766

Recently, targeted next generation sequencing (NGS) platforms have been introduced that allow inexpensive testing for hundreds of mutational hotspots at the same time. A number of additional mutational markers in thyroid cancer have been identified. Highly promising markers associated with tumor prognosis have also been found. This multi-institutional study aims to validate the diagnostic use of mutational markers in thyroid nodules with indeterminate cytology. The proposed hypothesis is that a broad NGS-based genotyping of thyroid nodules using a large panel of mutational markers applied to thyroid FNA samples can provide an accurate cancer risk stratification in thyroid nodules. The performance of the panel will be tested in a multi-institutional double-blind prospective study of FNA samples from thyroid nodules with indeterminate cytology and available surgical outcome

Thyroid Nodule

University of Pittsburgh256 participantsStarted Jan 2015

Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 3< 1 mile

Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)

NCT01919697

This is a multi-center, open-label, 52-week safety and tolerability study of plecanatide in patients with Chronic Idiopathic Constipation (CIC).

Chronic Idiopathic Constipation

Bausch Health Americas, Inc.2,370 participantsStarted Aug 2013

Birmingham, Alabama, United States • Dothan, Alabama, United States • Gulf Shores, Alabama, United States +217 more locations

Role of NGS-based ThyroSeq Panel in Cancer Diagnosis in Thyroid Nodules

Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)

Find Trials by Condition in Pittsburgh

Radiofrequency Ablation in Treating Patients With Bone Metastases

Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial)

Phase IV Study in Asthma Subjects for Dry Powder Inhaler (DPI) Versus (vs) Metered Dose Inhaler (MDI) Correct Use

AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease

ATHENA: Natural History of Disease Study in Alport Syndrome Patients

Two Daily Disposable Contact Lenses in Symptomatic Patients

Evaluation of the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance

Solace Stress Urinary inContinence Control Efficacy and Safety Study

Trial Comparing Three Different Devices for Kidney Stone Removal During Percutaneous Surgery

Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212

Continuation Study of the Oral AKT Inhibitor GSK2110183

Peanut Epicutaneous Phase II Immunotherapy Clinical Trial

Correlation of SOZO BIS Measures With CardioMEMS PA Pressure

A Study Evaluating Trastuzumab Emtansine Plus Pertuzumab Compared With Chemotherapy Plus Trastuzumab and Pertuzumab for Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Open-Label Study of INO-4212 With or Without INO-9012, Administered IM or ID Followed by Electroporation in Healthy Volunteers

A Study of Intratumoral CAVATAK™ in Patients With Stage IIIc and Stage IV Malignant Melanoma (VLA-007 CALM )

Dose Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of GSK2849330 in Subjects With Advanced Her3-Positive Solid Tumors

Efficacy and Safety Study of Deferiprone in Patients With Pantothenate Kinase-associated Neurodegeneration (PKAN)