Clinical Trials in Pittsburgh

Showing 10621-10640 of 21,047 trials

Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism

NCT01461304

This is a compassionate use study to allow patients already taking triheptanoin (C7) through previous studies to continue to receive the supplement. It will also allow triheptanoin supplementation in patients with qualifying disorders if they are failing conventional therapy.

Very Long-chain acylCoA Dehydrogenase (VLCAD) DeficiencyCarnitine Palmitoyltransferase Deficiencies (CPT1, CPT2)Mitochondrial Trifunctional Protein Deficiency+5 more

Jerry Vockley, MD, PhD

Pittsburgh, Pennsylvania, United States

TERMINATEDPhase 1/2< 1 mile

A Study of Obinutuzumab in Combination With Idasanutlin and Venetoclax in Participants With Relapsed or Refractory (R/R) Follicular Lymphoma (FL) or Rituximab in Combination With Idasanutlin and Venetoclax in Participants With R/R Diffuse Large B-Cell Lymphoma (DLBCL)

NCT03135262

This Phase Ib/II, open-label, multicenter, non-randomized, dose-escalation study will evaluate the safety, efficacy, and pharmacokinetics of obinutuzumab in combination with idasanutlin and venetoclax in participants with R/R FL and obinutuzumab or rituximab in combination with idasanutlin and venetoclax in participants with R/R DLBCL. The study will include an initial dose-escalation phase followed by an expansion phase. The dose-escalation phase is designed to determine the recommended phase II doses (RP2Ds) and regimen for idasanutlin and venetoclax in combination with obinutuzumab for FL participants and in combination with rituximab for DLBCL participants.

Follicular LymphomaLymphoma, Large B-Cell, Diffuse

Hoffmann-La Roche29 participantsStarted Jun 2017

Aurora, Colorado, United States • Chicago, Illinois, United States • Louisville, Kentucky, United States +18 more locations

Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism

A Study of Obinutuzumab in Combination With Idasanutlin and Venetoclax in Participants With Relapsed or Refractory (R/R) Follicular Lymphoma (FL) or Rituximab in Combination With Idasanutlin and Venetoclax in Participants With R/R Diffuse Large B-Cell Lymphoma (DLBCL)

Find Trials by Condition in Pittsburgh

A Study of Venetoclax and AMG 176 in Patients With Relapsed/Refractory Hematologic Malignancies

HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot Study

Stem Cell Transplant With Lenalidomide Maintenance in Patients With Multiple Myeloma (BMT CTN 0702)

Assessment of LBR-101 In Chronic Migraine

Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough

A Study of Pertuzumab With High-Dose Trastuzumab for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer (MBC) With Central Nervous System (CNS) Progression Post-Radiotherapy

The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Participants With Advanced Solid Tumors

Evaluation of PerioMonitor for Detection of Oral Inflammatory Load (OIL) in Human Subjects

Study of INCB053914 in Subjects With Advanced Malignancies

Nintedanib in Treating Patients With Malignant Pleural Mesothelioma That Is Recurrent

A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

A Study to Evaluate Ovarian Follicular Activity and Hormone Levels for DR-102 Compared to Two 28-Day Oral Contraceptives

Suprarenal Proximal Cuff Study for Treatment of Abdominal Aortic Aneurysm

Comparison of Two Bronchodilator Inhalers in Pediatric Asthmatics

Preoperative Chemotherapy and Bevacizumab in Patients With Stage IB (>4 cm), II, or Select Stage III NSCLC

An Extension Study to Evaluate the Long-term Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria

PREMOD2 With Near Infrared Spectroscopy Sub-study