Clinical Trials in Pittsburgh

Showing 1021-1040 of 21,047 trials

Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

NCT05380531

The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants

Cesarean Section ComplicationsOpioid Use

Senthil Sadhasivam700 participantsStarted Dec 2022

Indianapolis, Indiana, United States • St Louis, Missouri, United States • Pittsburgh, Pennsylvania, United States +1 more locations

RECRUITINGPhase 3< 1 mile

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

NCT06380751

The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positive, HER2-negative (defined as IHC 0, 1+, 2+/ ISH non-amplified) advanced breast cancer

Advanced Breast Cancer

AstraZeneca500 participantsStarted Aug 2024

Gilbert, Arizona, United States • Fountain Valley, California, United States • Glendale, California, United States +295 more locations

Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

Find Trials by Condition in Pittsburgh

Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin

Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease

PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease

Safety and Efficacy of APC-0101 in Preterm Infants With Respiratory Distress Syndrome

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections

A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to an Active Comparator in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis

A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphoma

Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange Arthroplasty

Clinical Decision Support Tool in PARDS Pilot Study

A Dose-finding Trial With Lu-AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments

A Study to Test Long-term Treatment With Brigimadlin in People With Solid Tumours Who Took Part in a Previous Study With This Medicine

A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief

A Study of Meaning-Centered Therapy for Mexican Adults With Advanced Cancer