Clinical Trials in Pittsburgh

Showing 9441-9460 of 16,007 trials

Safety Study on Stopping Anticoagulation Medication in Patients With a History of Atrial Fibrillation

NCT01650298

The purpose of this study is to determine whether it is safe to stop anticoagulation medication in patients with a history of atrial fibrillation (AF) based on information from a pacemaker or implantable cardioverter defibrillator (ICD).

Atrial Fibrillation

Abbott Medical Devices64 participantsStarted Jan 2013

Los Angeles, California, United States • Chicago, Illinois, United States • Boston, Massachusetts, United States +7 more locations

COMPLETEDPhase 2< 1 mile

Atorvastatin for Microvascular Endothelial Function and Raynaud in Early Diffuse Scleroderma

NCT02370784

The purpose of this study is to learn about the effect atorvastatin on blood vessel function and Raynaud symptoms in patients with early diffuse systemic sclerosis. Systemic sclerosis is a disease characterized by blood vessel injury, immune system activation and fibrosis. Blood vessel injury is thought to be important early in the disease. Blood vessel complications of systemic sclerosis include Raynaud phenomena, finger and toe ulcers, and pulmonary hypertension. While atorvastatin reduces cholesterol, it is recognized to have many effects beyond cholesterol reduction. These include improvement of blood vessel function and reduction of fibrosis. We hypothesize that treatment with atorvastatin over 16 weeks will improve blood vessel function and Raynaud symptom in patients with early diffuse systemic sclerosis. We hope that by targeting therapy early in the disease we may delay blood vessel changes and improve Raynaud symptoms.

Scleroderma

Robyn T. Domsic, MD, MPH24 participantsStarted Feb 2015

Pittsburgh, Pennsylvania, United States

Safety Study on Stopping Anticoagulation Medication in Patients With a History of Atrial Fibrillation

Atorvastatin for Microvascular Endothelial Function and Raynaud in Early Diffuse Scleroderma

Find Trials by Condition in Pittsburgh

Safety and Efficacy of a Lysophosphatidic Acid Receptor Antagonist in Idiopathic Pulmonary Fibrosis

A Study to Assess the Efficacy and Safety of Abatacept in Adults With Active Primary Sjögrens Syndrome

Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion

Study of the Safety, Pharmacodynamics, Efficacy, and PK of TIMP-GLIA in Subjects With Celiac Disease

A Rollover Safety Study of Lumacaftor/Ivacaftor in Subjects Aged 2 Years and Older With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Blood Sample Collection to Evaluate Biomarkers for Hepatocellular Carcinoma

Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment

Bortezomib, Ifosfamide, Carboplatin, and Etoposide, With or Without Rituximab, in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin Lymphoma

Study of the Native Outflow Tract Transcatheter Pulmonary Valve (TPV)

Clinical Evaluation of Etafilcon A Contact Lenses Using a Novel Manufacturing Technology

A Study That Compares the Extent to Which Apomorphine Becomes Available in the Body After Taking Either an Investigational Drug Containing Apomorphine or Apomorphine That is Injected Under the Skin in People With PD Complicated by "OFF" Episodes

Pazopanib Paediatric Phase II Trial Children's Oncology Group (COG) in Solid Tumors

Study of MLN2480 in Participants With Relapsed or Refractory Solid Tumors Followed by a Dose Expansion in Participants With Metastatic Melanoma

A Safety Study of NNZ-2566 in Pediatric Rett Syndrome

Dynamic Locking Screws 5.0 vs. Standard Locking Screws in Fracture of Distal Femur Treated With Locked Plate Fixation

TMT Fusion Plate vs. Two Crossed Screws

Performance Improvement Program on Imaging II

Prospective Multicenter Trial to Compare Preformed vs Non Preformed Orbital Implants