Clinical Trials in Pittsburgh

Showing 901-920 of 10,050 trials

Anticholinergic Deprescription in Schizophrenia

NCT06562608

In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with schizophrenia. Individuals identified by clinical services who have unneeded prescriptions benztropine or trihexyphenidyl will be eligible for deprescription and study entry. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will will be randomized to either staying on their anticholinergic drugs or undergoing deprescription per routine clinical care, and will undergo follow-up evaluations across 6 months. The investigators predict that reducing and deprescribing these drug, if clinically determined to be unnecessary will will enhance functioning, neurocognition

SchizophreniaSchizoaffective Disorder

Deepak K. Sarpal, M.D.105 participantsStarted Feb 2025

Pittsburgh, Pennsylvania, United States

RECRUITINGNA< 1 mile

Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis

NCT06857123

This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.

Knee Osteoarthristis

University of Pittsburgh20 participantsStarted Dec 2024

Pittsburgh, Pennsylvania, United States

Anticholinergic Deprescription in Schizophrenia

Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis

Find Trials by Condition in Pittsburgh

Suppression of Ovarian Function With Either Tamoxifen or Exemestane Compared With Tamoxifen Alone in Treating Premenopausal Women With Hormone-Responsive Breast Cancer

A Study to Evaluate the Safety and Effectiveness of the Rapidlink Device When Used in Patients Undergoing an Open Surgical Procedure to Repair the Aorta

Registry of the Patient Experience for Carpal Tunnel Release

A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight

A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors

A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity

A Longitudinal Observational Study of the Natural History and Management of Patients With HCC

Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)

Avapritinib Rollover Study

A Study to Learn About the Study Medicine Called PF-07258669 in Older Adults Including Those at Risk of Malnutrition

Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

A Study to Assess Recovery and Survival of Radiolabeled Apheresis Platelet Components Treated With the INTERCEPT Blood System for Platelets With LED Illuminator.

CLOZAPINE Response in Biotype-1

A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer

Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2