Clinical Trials in Pittsburgh

Showing 7861-7880 of 16,007 trials

A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction

NCT02980068

This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in healthy adult normal volunteers compared to volunteers with PH-HFpEF in the breakdown of oral nitrate.

Pulmonary; HypertensionHeart FailurePreserved Ejection Fraction

Gladwin, Mark, MD77 participantsStarted Aug 2017

Pittsburgh, Pennsylvania, United States • Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 1< 1 mile

Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease

NCT03065192

Safety and efficacy of AADC gene transfer in participants with Parkinson's disease.

Idiopathic Parkinson's DiseaseParkinson's DiseaseBasal Ganglia Disease+6 more

Neurocrine Biosciences16 participantsStarted May 2017

San Francisco, California, United States • Atlanta, Georgia, United States • Columbus, Ohio, United States +1 more locations

RECRUITINGPhase 1/2< 1 mile

KRT-232 and TKI Study in Chronic Myeloid Leukemia

NCT04835584

This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with Ph+ Chronic Myeloid Leukemia (CML) who have relapsed or are refractory or intolerant to a Tyrosine Kinase Inhibitor (TKI). This study is a global, open label Phase 1b/2 to determine the efficacy and safety of KRT-232 in patients with chronic phase CML (CML-CP) and accelerated phase (CML-AP) who have failed TKI treatments.

Chronic Myeloid Leukemia

Kartos Therapeutics, Inc.109 participantsStarted May 2021

Birmingham, Alabama, United States • Augusta, Georgia, United States • Pittsburgh, Pennsylvania, United States +23 more locations

A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction

Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease

KRT-232 and TKI Study in Chronic Myeloid Leukemia

Find Trials by Condition in Pittsburgh

Auriculotherapy for Surgical Pain

A Safety Study of LY3462817 and LY3509754 in Participants With Psoriasis

Phase 3b Safety and Efficacy Study of Apremilast to Treat Moderate to Severe Plaque-plaque Psoriasis

HTX-011 Administration Study in Planned Caesarean Section Procedure

A Comparison Between Two Post-operative Dressings

Mesenchymal Stem Cell Therapy for Knee Osteoarthritis

COVID-19 Progression in End-Stage Kidney Disease

A Study of GSK1349572 Versus Raltegravir (RAL) With Investigator Selected Background Regimen in Antiretroviral-Experienced, Integrase Inhibitor-Naive Adults

A Study to Assess the Impact of Omalizumab on Exercise Capacity, Physical Activity, and Sleep Quality in Participants With Moderate to Severe Allergic Asthma

CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures

A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia

A Study of Opaganib in Coronavirus Disease 2019 Pneumonia

The CO2RE® System for Vulvar Lichen Sclerosus

Next Generation Sequencing Versus Traditional Cultures for Clinically Infected Penile Implants: Impact of Culture Identification on Outcomes

Study to Evaluate Safety and Effectiveness of Oral Apremilast (CC-10004) in Patients With Moderate to Severe Plaque Psoriasis.

Safety and Efficacy of Isatuximab in Lymphoblastic Leukemia

CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy