Clinical Trials in Pittsburgh

Showing 7561-7580 of 16,007 trials

Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon Cancer

NCT02961374

This phase II trial studies the side effects of erlotinib hydrochloride and how well it works in reducing duodenal polyp burden in patients with familial adenomatous polyposis at risk of developing colon cancer. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Attenuated Familial Adenomatous PolyposisFamilial Adenomatous Polyposis

National Cancer Institute (NCI)46 participantsStarted Oct 2017

Scottsdale, Arizona, United States • Ann Arbor, Michigan, United States • Rochester, Minnesota, United States +5 more locations

COMPLETEDPhase 2< 1 mile

Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma

NCT01062425

This randomized phase II trial studies temozolomide, radiation therapy, and cediranib maleate to see how well they work compared with temozolomide, radiation therapy, and a placebo in treating patients with newly diagnosed glioblastoma (a type of brain tumor). Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high energy x-rays to kill tumor cells. Cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. It is not yet known whether temozolomide and radiation therapy are more effective when given with or without cediranib maleate in treating glioblastoma.

Adult GlioblastomaAdult Gliosarcoma

National Cancer Institute (NCI)261 participantsStarted Feb 2010

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Scottsdale, Arizona, United States +102 more locations

Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon Cancer

Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma

Find Trials by Condition in Pittsburgh

Study to Evaluate the Efficacy and Safety of Larazotide Acetate for the Relief of CeD Symptoms

A Study of ALKS 8700 in Adults With Relapsing Remitting Multiple Sclerosis (MS) EVOLVE-MS-1

A Study of Immune Responses to the Virus That Causes COVID-19

A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Adult Patients With Chronic Plaque Psoriasis

Trial of 4-Hydroxytamoxifen (4-OHT) Gel in Women Aimed at Reducing Dense Breast Tissue

A Clinical Trial of PRAX-114 in Participants With Major Depressive Disorder

A Study of PLX2853 in Advanced Malignancies.

Study to Compare Oral PF-06651600, PF-06700841 and Placebo in Subjects With Moderate to Severe Ulcerative Colitis

Safety, Tolerability and Efficacy on Low Density Lipoprotein Cholesterol (LDL-C) of Evolocumab in Participants With Human Immunodeficiency Virus (HIV) and Hyperlipidemia/Mixed Dyslipidemia

Efficacy and Safety of DaxibotulinumtoxinA for Injection to Treat Moderate to Severe Glabellar Lines

A Study Evaluating Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis and F/MF Genotypes

A Study of the Communication of Genetic Test Results By Telephone: A Multi-Center Study

Study of TER-101 Topical Ointment in Subjects With Atopic Dermatitis

Phase I/II Study of CK-101 in NSCLC Patients and Other Advanced Solid Tumors

A Trial of NOV-205 in Hepatitis C Patients Who Failed Standard Therapy

Postprandial Glycemic Response in Adults With Type 2 Diabetes

Infant Nutrition and Brain Development

Observational Study to Evaluate the Epidemiology of Surgical-induced Acute Kidney Injury