Clinical Trials in Pittsburgh

Showing 721-740 of 21,047 trials

Pupil-Indexed Noninvasive Neuromodulation

NCT06282406

Vagus nerve stimulation (VNS) is thought to activate neural pathways that release chemicals which promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical current applied to the external ear modulates physiological indexes of brain states implicated in the therapeutic effects of VNS. The broad objective of this project is to better understand physiological mechanisms modulated by auricular stimulation to support possible therapeutic effects in the form of motor learning.

Paresis

VA Office of Research and Development110 participantsStarted Jun 2024

Pittsburgh, Pennsylvania, United States

Active Not RecruitingPhase 3< 1 mile

Open-Label Extension of Zilucoplan in Subjects With Generalized Myasthenia Gravis

NCT04225871

The RAISE-XT study is an open-label extension study to evaluate the long-term efficacy, safety, and tolerability of zilucoplan in subjects with gMG who have previously participated in a qualifying Ra Pharmaceuticals sponsored zilucoplan study.

Generalized Myasthenia Gravis

UCB Biopharma SRL200 participantsStarted Dec 2019

Mobile, Alabama, United States • Phoenix, Arizona, United States • Irvine, California, United States +67 more locations

Pupil-Indexed Noninvasive Neuromodulation

Open-Label Extension of Zilucoplan in Subjects With Generalized Myasthenia Gravis

Find Trials by Condition in Pittsburgh

A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

Real-time Engagement for Learning to Effectively Control Type 2 Diabetes

ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors

Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Cancer Treatment

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma

Safety and Efficacy Study of VIS649 for IgA Nephropathy

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation

ORIC-114 in Combination With Subcutaneous Amivantamab in Patients With EGFR Exon20 Insertion Mutant NSCLC

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

A Study to Evaluate the Pharmacokinetics, Safety, and Effectiveness of Certolizumab Pegol in Children With Moderate to Severe Chronic Plaque Psoriasis

A Study to Assess the Effectiveness and Safety of 2 Dosage Regimens of Oral Fidrisertib (IPN60130) for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).

A Study of SmartFlow Magnetic Resonance (MR) Compatible Ventricular Cannula for Administering Eladocagene Exuparvovec to Pediatric Participants

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

Efficacy and Utility of Cxbladder Tests in Hematuria Patients

Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants

A Study of Baricitinib (LY3009104) in Children and Adolescents With Atopic Dermatitis