Clinical Trials in Pittsburgh

Showing 6121-6140 of 16,007 trials

Blinded Dry Mouth Spray Crossover Study

NCT04608773

To identify the effectiveness of two mouth sprays at relieving symptoms of xerostomia in patients who have received radiation for carcinoma of the head and neck. To assess patient quality of life and mouth acidity following use of two mouth sprays meant to relieve symptoms of xerostomia in patients who have received radiation for carcinoma of the head and neck.

XerostomiaHead and Neck CancerXerostomia Following Radiotherapy

Jonas Johnson129 participantsStarted Jan 2021

Pittsburgh, Pennsylvania, United States • Pittsburgh, Pennsylvania, United States

UNKNOWN< 1 mile

Radiotherapy With Iron Oxide Nanoparticles (SPION) on MR-Linac for Primary & Metastatic Hepatic Cancers

NCT04682847

There is a high prevalence of hepatic cirrhosis in patients with hepatocellular carcinomas (HCC), or chemotherapy-induced hepatic atrophy or hepatosteatosis in patients with liver metastases associated with high risk of radiation-induced liver disease (RILD) after stereotactic body radiotherapy (SBRT). MRI-SPION radiotherapy planning will facilitate detection and maximize avoidance of residual functionally active hepatic parenchyma from over-the-threshold irradiation thus increasing safety of liver SBRT in patients with pre-existing liver conditions. The investigators have previously demonstrated that liver SBRT with SPECT/CT functional treatment planning utilizing 99mTc sulfur colloid in transplant eligible patients associated with minimal hepatotoxicity and without hastening of advanced hepatic cirrhosis progression while patients await liver transplant. Switching from nuclear medicine to an MR-Linac-SPION based quantitative treatment-planning platform will substantially improve diagnostic accuracy in defining safe volumes of residual functional hepatic parenchyma for liver SBRT planning on MR-Linac.

Liver NeoplasmsHepatic CirrhosisHepatic Carcinoma+6 more

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)40 participantsStarted Nov 2020

Pittsburgh, Pennsylvania, United States

Blinded Dry Mouth Spray Crossover Study

Radiotherapy With Iron Oxide Nanoparticles (SPION) on MR-Linac for Primary & Metastatic Hepatic Cancers

Find Trials by Condition in Pittsburgh

Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery

Balancing Method for Pain Related to Advanced Cancer

Identifying Learning Strategies to Improve Blood Pressure Measurement in Physical Therapy Education Programs

Study to Evaluate the Efficacy and Safety of FX006 in Patients With Hip Osteoarthritis

Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee

Study to Evaluate the Iovera° Device for Temporary Relief From Knee Pain

A Phase 1/2, First-in-Human, Open Label, Dose Escalation Study Of A CSP Targeting Functional Antibody in Solid Tumors

BIO 300 Non-Small Cell Lung Cancer Study

Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma

Optimizing Video Communication Assessment for Teaching Error Disclosure Skills

Study in Subjects With Small Primary Choroidal Melanoma

Nu-3 Topical Gel for Treatment of Diabetic Foot Ulcer

Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)

A Study of mRNA-1020 and mRNA-1030 Seasonal Influenza Vaccines in Healthy Adults

A Study of Melphalan Flufenamide (Melflufen)-Dex or Pomalidomide-dex for RRMM Patients Refractory to Lenalidomide

Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip

Study on Efficacy and Safety of LNP023 in C3 Glomerulopathy Patients Transplanted and Not Transplanted