Clinical Trials in Pittsburgh

Showing 5621-5640 of 16,007 trials

C-myc Biomarker Study for Diabetic Foot Ulcers

NCT04591691

This is a multi-center observational cohort study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict complete wound healing. Eligible and consented participants will begin standard of care treatment after collection of tissue specimens from the wound's edge. An additional tissue specimen is collected at 4 weeks if clinically indicated. Tissues will be tested for c-myc and phosphorylated glucocorticoid receptor (p-GR) levels using validated protocols at a central laboratory. Participants will be followed weekly for up to 12 weeks or until complete wound healing (whichever occurs first). One final assessment 2 weeks after complete wound healing will occur to confirm healing.

DiabetesDiabetic FootDiabetic Foot Ulcer+1 more

University of Michigan140 participantsStarted Oct 2020

San Francisco, California, United States • Stanford, California, United States • Miami, Florida, United States +3 more locations

RECRUITINGPhase 3< 1 mile

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

NCT02735707

REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19. REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America.

Community-acquired Pneumonia, Influenza, COVID-19

UMC Utrecht20,000 participantsStarted Apr 2016

Jacksonville, Florida, United States • Augusta, Georgia, United States • Chicago, Illinois, United States +405 more locations

C-myc Biomarker Study for Diabetic Foot Ulcers

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Find Trials by Condition in Pittsburgh

Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children With Urea Cycle Disorders

Study of the Safety of HPN (Hyperion)-100 for the Long-Term Treatment of Urea Cycle Disorders (Treat UCD)

Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 (PD-L1) Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Efficacy and Safety of HPN-100 for the Treatment of Adults With Urea Cycle Disorders

A Study to Find Out How Nintedanib is Taken up in the Body and How Well it is Tolerated in Children and Adolescents With Interstitial Lung Disease (ILD)

Leidos-Enabled Adaptive Protocol (LEAP-CT) for Evaluation of Post-exposure Prophylaxis for Newly-infected COVID-19 Patients

Filgotinib in Long-Term Extension Study of Adults With Crohn's Disease

A Study of the Safety, Efficacy, and Biomarker Response of BMS-986165 in Participants With Moderate to Severe Ulcerative Colitis

Temsirolimus Alone or Paired With Dexamethasone Delivered to the Adventitia to eNhance Clinical Efficacy After Femoropopliteal Revascularization

Study to Assess the Efficacy and Safety of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

A Safety and Effectiveness Study of a New Preservative Free Rewetting Drop

Sleep Signal Analysis for Current Major Depressive Episode (SAMDE)

Confirmation of Diet as a Treatment for Gulf War Illness

TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence

Feasibility Study on LITT for Medical Refractory Epilepsy

Safety and Efficacy of ARQ-252 Cream 0.3% in Subjects With Non-Segmental Facial Vitiligo

Phase Ib/2, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Hepatocellular Carcinoma

Impact of Microvascular Inflammation on Kidney Allograft Outcome