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Clinical Trials in Philadelphia | 9,968 Studies Near You | Clareo Health

Clinical Trials LocationsPhiladelphia

Clinical Trials in Philadelphia

Discover 9,968 clinical trials near Philadelphia, Pennsylvania. Find research studies in your area.

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Showing 1701-1720 of 9,968 trials

RECRUITINGPhase 2< 1 mile

NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

NCT06450041

This is a phase II study looking at patient response to treatment with the combination dinutuximab, temozolomide, irinotecan, and GM-CSF.

New Approaches to Neuroblastoma Therapy Consortium62 participantsStarted Dec 2024

Los Angeles, California, United States • San Francisco, California, United States • Aurora, Colorado, United States +10 more locations

Active Not RecruitingPhase 3< 1 mile

A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)

NCT05882877

The primary objective of this study is to describe the long-term safety and tolerability of rocatinlimab in participants with moderate-to-severe AD.

Atopic Dermatitis

Amgen2,621 participantsStarted May 2023

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Phoenix, Arizona, United States +544 more locations

Find Trials by Condition in Philadelphia

Breast Cancerin Philadelphia Lung Cancerin Philadelphia Prostate Cancerin Philadelphia Colorectal Cancerin Philadelphia Melanomain Philadelphia Leukemiain Philadelphia Lymphomain Philadelphia Pancreatic Cancerin Philadelphia Ovarian Cancerin Philadelphia Brain Cancerin Philadelphia

Data from ClinicalTrials.govTerms

Active Not RecruitingPhase 2< 1 mile

Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I)

NCT04439227

This phase II MATCH treatment trial identifiesay block the protein tyrosine kinase WEE1 the effects of AZD1775 in patients whose cancer has a genetic change called BRCA mutation. AZD1775 may block a protein called WEE1, which may be needed for growth of cancer cells that express BRCA mutations. Researchers hope to learn if AZD1775 will shrink this type of cancer or stop its growth.

Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more

National Cancer Institute (NCI)35 participantsStarted Mar 2017

Philadelphia, Pennsylvania, United States

Active Not RecruitingPhase 3< 1 mile

Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1

NCT05680818

The primary purpose of the study is to understand the effectiveness, safety, and tolerability of encaleret when compared to standard of care (SoC) treatment in participants with Autosomal Dominant Hypocalcemia Type 1 (ADH1).

Autosomal Dominant Hypocalcemia (ADH)

Calcilytix Therapeutics, Inc., a BridgeBio company67 participantsStarted Jan 2023

Oakland, California, United States • Aurora, Colorado, United States • Indianapolis, Indiana, United States +22 more locations

Active Not RecruitingPhase 2< 1 mile

SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST

NCT06208748

This is an open label, single arm, phase 2 trial investigating bezuclastinib plus sunitinib in patients with GIST who have previously progressed on sunitinib.

Gastrointestinal Stromal TumorsGIST

Sarcoma Alliance for Research through Collaboration40 participantsStarted Aug 2024

Miami, Florida, United States • Boston, Massachusetts, United States • Portland, Oregon, United States +1 more locations

Active Not RecruitingNA< 1 mile

Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD

NCT04229017

This study will evaluate the safety and effectiveness of a device called "Posterior Cervical Stabilization System or PCSS" when used along with posterior cervical fusion (PCF) in combination with anterior cervical discectomy and fusion (ACDF) in the treatment of multi-level cervical degenerative disease.

Degenerative Disc Disease

Providence Medical Technology, Inc.236 participantsStarted Mar 2020

Phoenix, Arizona, United States • Encinitas, California, United States • Los Gatos, California, United States +14 more locations

COMPLETEDPhase 13.0 miles

Localized Injection of Lidocaine and Glucocorticoid for Headache Treatment Phase 1

NCT06462781

The goal of this clinical trial is to test whether injecting lidocaine and steroids into two blood vessels of the brain can help treat chronic headaches (migraines). The main questions this study aims to answer: is this treatment safe for chronic migraine patients? Participants will: * Be treated once with lidocaine and steroid infused into the middle meningeal arteries (two blood vessels in the brain). * Attend appointments scheduled 1 week, 6 weeks, and 12 weeks after the treatment for a checkup. * Keep a log of their symptoms.

Refractory Migraine

The Cooper Health System10 participantsStarted Mar 2024

Camden, New Jersey, United States

Active Not RecruitingPhase 248 miles

Study to Assess the Efficacy & Safety of KHK4951 in Patients With Diabetic Macular Edema

NCT06116916

The purpose of this study is to evaluate efficacy and safety of KHK4951 eye drops in patients with DME.

Diabetic Macular Edema (DME)

Kyowa Kirin Co., Ltd.150 participantsStarted Jan 2024

Mesa, Arizona, United States • Tucson, Arizona, United States • Arcadia, California, United States +84 more locations

RECRUITING55 miles

Rutgers University Study of the Genetics of Kidney Disease

NCT07217535

The goal of this observational study is to learn more about how genes impact the risk of kidney disease. Anyone 18 or older living in the US is eligible, and a diagnosis of kidney disease is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.

Kidney DiseaseKidney Disease, ChronicKidney Disease, End-Stage+3 more

Rutgers, The State University of New Jersey50,000 participantsStarted Nov 2025

Piscataway, New Jersey, United States

RECRUITINGNA55 miles

DECIDE to Improve Maternal Mental Health Care Delivery

NCT07098260

Appropriate training for perinatal mental health care is an important public health concern as mental health disorders are common pregnancy complications. Perinatal and mental health care providers report the difficulty of treating perinatal individuals due to insufficient information available regarding mental health treatment decisions, differences in beliefs and attitudes, and concerns about adverse effects on patients, such as self-harm and suicide. Effective shared decision-making skills can improve perinatal and mental health care providers' competencies to meet the unique decision needs of perinatal individuals, particularly those with mental health disorders. The proposed project titled "DECIDE to Improve Maternal Mental Health Care Delivery" aims to adapt the DECIDE Provider Training developed by Dr. Alegria and her team,1 to improve the rapid and wide dissemination and implementation of DECIDE in meeting the mental health needs of perinatal individuals. DECIDE stands for Decide the problem; Explore the questions; Closed or open-ended questions; Identify the who, why, or how of the problem; Direct questions to your health care professional; Enjoy a shared solution. The DECIDE provider training was developed based on theories of intergroup contact in social psychology and a patient-centered framework.28-30 DECIDE teaches mental health providers how to improve perspective-taking, reduce attributional errors, and increase receptivity to the client population.1,15-17 The proposed project will (1) make content adaptation (i.e., adding topical training content to fit perinatal mental health care) and process adaption (i.e., creating asynchronous training modules to reduce the burden for care providers) to the DECIDE Provider Training and (2) assess the acceptability, appropriateness, and usability of adapted DECIDE provider training for rapid and wide dissemination and implementation of DECIDE in maternal mental health care delivery.

Mental Health Disorders

Rutgers, The State University of New Jersey35 participantsStarted Feb 2025

Piscataway, New Jersey, United States

COMPLETEDNA80 miles

Clinical Validation Study of the Eximis CS (Contained Segmentation) System

NCT06572163

The purpose of this study is to evaluate device safety and effectiveness of the Eximis CS System.

Laparoscopic Gynecological Surgical Procedures

Eximis Surgical23 participantsStarted Sep 2024

Celebration, Florida, United States • Idaho Falls, Idaho, United States • Brooklyn, New York, United States +1 more locations

RECRUITINGPhase 1/281 miles

A Phase 1/2a to Evaluate the Safety and Efficacy of Adipose Tissue Allograft (BRC-OA) in Patients With Osteoarthritis of the Knee

NCT06828666

The purpose of this study is to evaluate the safety profile of BRC-OA for pain treatment in patients with mild to severe OA of the knee, focusing particularly on two distinct doses. Alongside safety assessments, the study also aims to investigate the initial efficacy of BRC-OA in treating pain among these patients. The study product is a cryopreserved devitalized adipose tissue allograft (BRC-OA). BRC-OA is composed of a devitalized human adipose particulate that retains the inherent properties of adipose such as tissue architecture, extracellular matrix, and signaling molecules.

Osteoarthritis of Knee

Britecyte42 participantsStarted May 2025

Baltimore, Maryland, United States • Hagerstown, Maryland, United States • Oxon Hill, Maryland, United States +4 more locations

COMPLETEDPhase 281 miles

Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

NCT05103332

The purpose of this study is to evaluate the effect of zilebesiran on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of zilebesiran as add-on therapy.

Alnylam Pharmaceuticals663 participantsStarted Nov 2021

Mesa, Arizona, United States • Tempe, Arizona, United States • Tempe, Arizona, United States +107 more locations

TERMINATEDPhase 381 miles

To Evaluate Safety and Tolerability of the Fixed- Dose Combination of Obeticholic Acid and Bezafibrate

NCT06488911

An Open Label Long-Term Study to Evaluate the Safety and Tolerability of the Fixed-Dose Combination (FDC) of Obeticholic Acid (OCA) and Bezafibrate (BZF) tablet in Subjects with Primary Biliary Cholangitis (PBC).

Primary Biliary Cholangitis

Intercept Pharmaceuticals63 participantsStarted Jul 2024

Birmingham, Alabama, United States • Coronado, California, United States • Tampa, Florida, United States +48 more locations

RECRUITINGNA81 miles

Evaluate the Safety and Effectiveness of the Polymotion Hip Resurfacing (PHR) System Compared to Total Hip Arthroplasty

NCT06792539

The goal of this clinical trial is to evaluate the safety and effectiveness of the Polymotion Hip Resurfacing (PHR) System compared to total hip arthroplasty, for adults who require hip resurfacing arthroplasty due to 1) non-inflammatory arthritis (degenerative joint disease) such as osteoarthritis, traumatic arthritis, or 2) mild dysplasia/developmental dislocation of the hip (DDH) up to Crowe Grade 1.

Osteoarthritis of the HipDegenerative Joint Disease of HipDysplasia; Hip

JointMedica Inc.238 participantsStarted Jan 2025

Tampa, Florida, United States • Chicago, Illinois, United States • Baltimore, Maryland, United States +7 more locations

RECRUITINGPhase 390 miles

ZILRETTA in Subjects With Shoulder Osteoarthritis

NCT06269705

Primary Objective: To assess the efficacy of ZILRETTA on pain following an intra-articular (IA) injection in subjects with glenohumeral osteoarthritis (OA) relative to normal saline placebo Secondary Objective: * To assess the efficacy of ZILRETTA on pain following an IA injection in subjects with glenohumeral OA relative to triamcinolone acetonide injectable suspension, and normal saline placebo * To assess the safety of ZILRETTA in subjects with glenohumeral OA relative to normal saline placebo

Glenohumeral Osteoarthritis

Pacira Pharmaceuticals, Inc150 participantsStarted Feb 2024

Vestavia Hills, Alabama, United States • Surprise, Arizona, United States • Tucson, Arizona, United States +29 more locations

RECRUITINGPhase 1/2138 miles

A Modular Phase 1/2 Study With CT7439 in Participants With Solid Malignancies

NCT06600789

This modular, multi-part, multi-arm, Phase 1/2, FIH study allows the evaluation of the safety and tolerability of CT7439, dosed as a monotherapy and in combination with anticancer treatment in participants with solid malignancies.

Solid Malignancies

Carrick Therapeutics Limited50 participantsStarted Aug 2024

Dallas, Texas, United States • San Antonio, Texas, United States • Fairfax, Virginia, United States +3 more locations

RECRUITINGPhase 3271 miles

PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.

NCT06274047

1. Personalize treatment for prostate cancer based on how aggressive the disease is and 2. Learn if apalutamide-based treatment can help to reduce fatigue and other side effects of treatment in participants who are being treated with radiation therapy for prostate cancer, as compared to standard therapy.

Androgen Axis SuppressionProstatectomyProstate Cancer

M.D. Anderson Cancer Center120 participantsStarted Sep 2024

Kansas City, Kansas, United States • Boston, Massachusetts, United States • Houston, Texas, United States

RECRUITING271 miles

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

NCT06934876

This study will compare the sensitivity and specificity of waveform capnography versus colorimetric carbon dioxide detection to identify tracheal placement of the endotracheal tube during intubation of critically ill adults.

Acute Respiratory Failure

Brian Driver1,332 participantsStarted Apr 2025

Burlington, Massachusetts, United States • Minneapolis, Minnesota, United States • Durham, North Carolina, United States +3 more locations

Active Not Recruiting384 miles

Sex-specific Risk Factors and Trajectories of Blood Biomarkers for Alzheimer's Disease and Related Dementias

NCT07224139

Blood-based ADRD biomarkers show tremendous promise as a non-invasive method to predict and diagnose ADRD. We will measure changes in these biomarkers to determine whether their ability to predict ADRD differs by sex or by other characteristics, and develop a sex-specific ADRD risk score for personalized medicine and clinical trials.

Alzheimer DiseaseDementiaCognitive Dysfunction

Anne Murray13,435 participantsStarted Jul 2022

Decatur, Georgia, United States • Minneapolis, Minnesota, United States • Minneapolis, Minnesota, United States +2 more locations

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