Clinical Trials in Philadelphia

Showing 11601-11620 of 17,926 trials

Safety and Tolerability Study of 2 Dose Level of Arikayce™ in Patients With Bronchiectasis and Chronic Infection Due to Pseudomonas Aeruginosa.

NCT00775138

This is a study to determine the safety and tolerability of 28 days of daily dosing of two doses (280 mg and 560 mg) of Arikayce™ versus placebo in patients who have bronchiectasis and chronic infection due to Pseudomonas infection.

Bronchiectasis

Insmed Incorporated64 participantsStarted Jun 2008

Washington D.C., District of Columbia, United States • Philadelphia, Pennsylvania, United States • Sofia, Bulgaria +15 more locations

COMPLETEDPhase 2< 1 mile

Noninvasive, Subharmonic Intra-Cardiac Pressure Measurement

NCT03243942

The fundamental hypothesis of this project is that real-time intracardiac pressures can be monitored and quantified noninvasively in humans using a novel contrast-enhanced ultrasound technique called subharmonic-aided pressure estimation (SHAPE).This study will use contrast echocardiography to assess the accuracy of SHAPE compared to simultaneously acquired intracardiac pressures measured invasively during cardiac catheterization. This study is designed to verify that contrast echocardiography using the SHAPE method, already proven in a canine model and tested in a human pilot study can be used as a surrogate for cardiac catheterization with sufficient accuracy to allow clinical applicability in humans.

Cardiac CatheterizationBlood PressureHeart Ventricles+2 more

Thomas Jefferson University56 participantsStarted Jun 2017

Philadelphia, Pennsylvania, United States

Safety and Tolerability Study of 2 Dose Level of Arikayce™ in Patients With Bronchiectasis and Chronic Infection Due to Pseudomonas Aeruginosa.

Noninvasive, Subharmonic Intra-Cardiac Pressure Measurement

Find Trials by Condition in Philadelphia

Study Of The Effectiveness & Safety Of Lenalidomide Versus Chlorambucil As First Line Therapy For Elderly Patients With B-Cell CLL (The ORIGIN Trial)

Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212

Radiofrequency Ablation in Treating Patients With Bone Metastases

Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)

The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty

AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease

Evaluation of the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance

A Study of Intratumoral CAVATAK™ in Patients With Stage IIIc and Stage IV Malignant Melanoma (VLA-007 CALM )

Continuation Study of the Oral AKT Inhibitor GSK2110183

ATHENA: Natural History of Disease Study in Alport Syndrome Patients

Dose Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of GSK2849330 in Subjects With Advanced Her3-Positive Solid Tumors

Peanut Epicutaneous Phase II Immunotherapy Clinical Trial

Phase IV Study in Asthma Subjects for Dry Powder Inhaler (DPI) Versus (vs) Metered Dose Inhaler (MDI) Correct Use

A Study Evaluating Trastuzumab Emtansine Plus Pertuzumab Compared With Chemotherapy Plus Trastuzumab and Pertuzumab for Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Solace Stress Urinary inContinence Control Efficacy and Safety Study

Two Daily Disposable Contact Lenses in Symptomatic Patients

Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis

Efficacy and Safety Study of Deferiprone in Patients With Pantothenate Kinase-associated Neurodegeneration (PKAN)