Clinical Trials in Philadelphia

Showing 10281-10300 of 17,926 trials

Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas

NCT01024907

RATIONALE: Specialized radiation therapy, such as proton beam radiation therapy, that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase I/II trial is studying the best way to give proton beam radiation therapy and to see how well it works in treating patients with low grade gliomas.

Adult Brain TumorAdult Brain Stem GliomaAdult Diffuse Astrocytoma+9 more

Abramson Cancer Center at Penn Medicine23 participantsStarted Dec 2009

Philadelphia, Pennsylvania, United States

COMPLETEDPhase 1< 1 mile

Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

NCT00135005

This study is an open-label, multicenter, Phase I dose-escalation study of the combination of AMN107 and imatinib (STI571) in patients with imatinib-resistant GIST. This study is designed to determine the Phase II dose of AMN107 and imatinib when administered together in patients with imatinib-resistant GIST, and to characterize the safety, tolerability and pharmacokinetic (PK) profile of this combination.

Gastrointestinal Stromal Tumors

Novartis Pharmaceuticals59 participantsStarted Aug 2005

Boston, Massachusetts, United States • Philadelphia, Pennsylvania, United States • Lyon, France +2 more locations

TERMINATEDPhase 117 miles

Pharmacokinetics of Dabrafenib in Subjects With Hepatic Impairment

NCT02873650

To characterize the pharmacokinetics and safety of dabrafenib following a single 100 mg oral dose in subjects with moderate and severe hepatic impairment.

Hepatic Impairment

Novartis Pharmaceuticals5 participantsStarted Dec 2016

Los Angeles, California, United States • DeBary, Florida, United States • Berlin, New Jersey, United States +1 more locations

Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas

Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

Pharmacokinetics of Dabrafenib in Subjects With Hepatic Impairment

Find Trials by Condition in Philadelphia

Investigate Effect of Secukinumab on the PK of Midazolam in Patients With Mod to Sev Plaque Psoriasis

An Efficacy and Safety Study of BG00011 in Participants With Idiopathic Pulmonary Fibrosis

Phase 1b Trial of BGJ398/BYL719 in Solid Tumors

A Phase I Study for Safety and Tolerability of AL002.

Twenty-Four Month Extension Study of BA058-05-003 (Abaloparatide) in Participants With Osteoporosis

A Study Evaluating the Safety and Efficacy of Topical BPR277 for the Treatment of Atopic Dermatitis and Netherton Syndrome

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose CFZ533 in Rheumatoid Arthritis Patients

Exploratory Study of KPI-121 Effect on Intra- or Subretinal Fluid Due to Retinal Vein Occlusion/Diabetic Macular Edema

A Study of MEK162 and AMG 479 in Patients With Selected Solid Tumors

A Study to Investigate Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of BKM120 Plus GSK1120212 in Selected Advanced Solid Tumor Patients

Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy

Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)

Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib

Safety, Tolerability, and Efficacy Study of CLL442 in Patients With Cutaneous Squamous Cell Carcinoma in Situ (SCCis)

Study to Evaluate the Pharmacokinetics of Tenofovir Alafenamide (TAF) in Adults With Normal Hepatic Function and Adults With Severe Hepatic Impairment

Combination of AUY922 With Trastuzumab in HER2+ Advanced Breast Cancer Patients Previously Treated With Trastuzumab

Masitinib in the Treatment of Patients With Severe Uncontrolled Asthma and Elevated Eosinophil Levels