Clinical Trials in Philadelphia

Showing 9301-9320 of 15,860 trials

Multi-Center Study of Iron Overload: Survey Study (MCSIO)

NCT01913548

The purpose of this study is to demonstrate that a sufficient number of iron-overloaded thalassemia (THAL), Sickle Cell Disease (SCD)and Diamond Blackfan Anemia (DBA) populations with similar duration of chronic transfusion, and age at start of transfusions would be available for a confirmatory study. The study will examine the hypothesis that a chronic inflammatory state in SCD leads to hepcidin- and cytokine-mediated iron withholding within the RES (reticuloendothelial system), lower plasma NTBI (non-transferrin bound iron) levels, less distribution of iron to the heart in SCD.

Sickle Cell DiseaseThalassemiaDiamond-Blackfan Anemia

UCSF Benioff Children's Hospital Oakland423 participantsStarted Mar 2010

Oakland, California, United States • Augusta, Georgia, United States • Chicago, Illinois, United States +5 more locations

COMPLETEDPhase 1< 1 mile

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Voxilaprevir in Adults With Chronic Hepatitis C Virus Infection

NCT02185794

The primary objective of the study is to evaluate the safety and tolerability of voxilaprevir (formerly GS-9857) alone or with sofosbuvir (SOF)/velpatasvir (VEL) fixed dose combination (FDC) and antiviral activity of voxilaprevir in adults with genotype 1, 2, 3, 4 hepatitis C virus (HCV) infection. All participants will be monitored for up to 48 weeks after the last dose.

Hepatitis C Virus Infection

Gilead Sciences101 participantsStarted Jun 2014

Costa Mesa, California, United States • DeLand, Florida, United States • Orlando, Florida, United States +8 more locations

Multi-Center Study of Iron Overload: Survey Study (MCSIO)

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Voxilaprevir in Adults With Chronic Hepatitis C Virus Infection

Find Trials by Condition in Philadelphia

Pediatric Continuity Care Intensivist

High Flow Therapy (HFT) to Treat Respiratory Insufficiency in Chronic Obstructive Pulmonary Disease (COPD)

A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)

Dose Finding Study to Treat High Phosphate Levels in the Blood.

Evaluation of Safety and Exploratory Efficacy of an Autologous Adipose-derived Cell Therapy Product for Treatment of Single Knee Osteoarthritis

A Study to Evaluate the Safety, Tolerability & Efficacy of MSDC-0602K in Patients With NASH

Study to Evaluate the Efficacy and Safety of Andecaliximab Combined With Nivolumab Versus Nivolumab Alone in Adults With Unresectable or Recurrent Gastric or Gastroesophageal Junction Adenocarcinoma

A Study of Filanesib (ARRY-520) and Carfilzomib in Patients With Advanced Multiple Myeloma

Multidimensional System to Dynamically Predict Graft Survival After Kidney Transplantation

PROMINENT-Eye Ancillary Study (Protocol AD)

A Study of MEK162 and Paclitaxel in Patients With Epithelial Ovarian, Fallopian Tube or Peritoneal Cancer

Oral Iron for Erythropoietic Protoporphyrias

Dose-Finding Study Comparing the Safety and Efficacy of Latanoprost to a Novel Treatment for Glaucoma

A Study to Assess Resistance and Durability of Response to ABT-493 and/or ABT-530

A Study of BYL719 in Adult Patients With Advanced Solid Malignancies, Whose Tumors Have an Alteration of the PIK3CA Gene

A Treatment-Option Protocol to Provide Brentuximab Vedotin to Eligible Patients Completing Studies SGN35-005 or C25001

A Study of Tucatinib (ONT-380) Combined With Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2+ Breast Cancer

Pediatric Acute Gastrointestinal Bleeding Registry