Clinical Trials in Philadelphia

Showing 9221-9240 of 15,860 trials

Depletion of Myeloid Derived Suppressor Cells to Enhance Anti PD-1 Therapy

NCT03302247

Metastatic non small cell lung cancer can be treated with cytotoxic chemotherapy or using recently approved immunotherapy with antibody, Nivolumab. Both the therapies have limitation due to development of tolerance or immunosuppression. This trial combines one drug from each category, immunotherapeutic Nivolumab and chemotherapeutic gemcitabine as it was reported that gemcitabine reduces immunosuppression by killing myeloid derived suppressor cells, thereby increasing the efficacy of Nivolumab.

Non Small Cell Lung Cancer Stage IIIB

Fox Chase Cancer Center3 participantsStarted Jan 2018

Philadelphia, Pennsylvania, United States

UNKNOWNNA< 1 mile

Randomized Trial of COBRA PzF Stenting to Reduce Duration of Triple Therapy

NCT02594501

The purpose of this study is to determine whether patients undergoing coronary intervention that also require oral anticoagulation, treatment with the COBRA PzF stent plus 14-day dual anti-platelet therapy (DAPT) has higher safety and non-inferior outcomes for thrombo-embolic events than compared with standard FDA-approved drug eluting stent (DES) plus 3 or 6-month DAPT.

Angina, StableAngina, UnstableAnticoagulants

CeloNova BioSciences, Inc.996 participantsStarted Feb 2016

Newark, Delaware, United States • Jacksonville, Florida, United States • Jacksonville, Florida, United States +45 more locations

Depletion of Myeloid Derived Suppressor Cells to Enhance Anti PD-1 Therapy

Randomized Trial of COBRA PzF Stenting to Reduce Duration of Triple Therapy

Find Trials by Condition in Philadelphia

Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-Related Macular Degeneration (AMD)

The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias

Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches

Safety and Efficacy of OT-82 in Participants With Relapsed or Refractory Lymphoma

Evaluation of Memory Skills in Patients Receiving Radiation Therapy for Brain Metastases

Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer

Postplacental LNG-IUD Ultrasound Use Study

A Study to Assess Safety and Efficacy of KarXT in Adult Patients With Schizophrenia

Study to Evaluate the Safety and Effectiveness of the CODMAN ENTERPRISE® Vascular Reconstruction Device

Temozolomide Plus Radiation Therapy in Treating Patients With Newly Diagnosed Anaplastic Oligodendrogliomas or Mixed Anaplastic Oligoastrocytomas

A Phase 2, Study of Ficlatuzumab Plus Erlotinib vs. Placebo Plus Erlotinib in Subjects With Previously Untreated Metastatic, EGFR-mutated NSCLC and BDX004 Positive Label

Topical Rapamycin to Erase Angiofibromas in TSC

Type 1 Diabetes and the Brain in Children

Danirixin Dose Ranging Study in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Cholinesterase Inhibitor Discontinuation

Sebacia Postmarket Study of Real-World Use

Safety and Efficacy of Melflufen and Dexamethasone in Relapsed and/or Relapsed-Refractory Multiple Myeloma Patients

Clinical Trial Evaluating Acutrak Headless Compression Screw Fixation of Medial Malleolus Fractures