Clinical Trials in Philadelphia

Showing 9181-9200 of 15,860 trials

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

NCT00031083

In this study an investigational replication-defective, recombinant adenovirus expressing the interferon-beta gene (BG00001) will be directly injected into tumors, in patients with recurrent Grade III and Grade IV Gliomas, in order to deliver the hIFN-beta gene. The purpose of the study is to evaluate the safety and any harmful effects of injection of BG00001 into brain tumors. Also, this study will help determine whether the virus carrying the beta interferon gene will enter brain tumor cells and cause the cancer cells to die. This study will require one hospital admission for the actual procedure of drug administration. All other visits will be conducted on an out-patient basis

Glioblastoma MultiformeAnaplastic AstrocytomaOligoastrocytoma, Mixed+1 more

Biogen12 participantsStarted Apr 2002

Birmingham, Alabama, United States • Tucson, Arizona, United States • Denver, Colorado, United States +2 more locations

WITHDRAWNPhase 2< 1 mile

Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc)

NCT04138485

This randomized, multicenter, double-blind (DB), placebo controlled, phase 2 study will evaluate the efficacy and safety of IgPro10. The DB Treatment Period will be followed by a 24-week Open-label (OL) Treatment Period. Eligible subjects will be randomized at Baseline in a 2:1 ratio of treatment IgPro10 or placebo in the DB Treatment Period. All subjects who enter OL Treatment Period will receive IgPro10.

Diffuse Cutaneous Systemic Sclerosis

CSL BehringStarted Dec 2019

Scottsdale, Arizona, United States • Los Angeles, California, United States • Los Angeles, California, United States +74 more locations

Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas

Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc)

Find Trials by Condition in Philadelphia

A Women-Focused PrEP Intervention

Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogens

A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)

Safety and Efficacy of Switching From Dolutegravir and ABC/3TC or ABC/DTG/3TC to B/F/TAF in HIV-1 Infected Adults Who Are Virologically Suppressed

Cognitive Impairement In Frontotemporal Dementia

Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease

Study Comparing the Safety and Efficacy of Two Doses of BC-3781 vs Vancomycin in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI)

Occipital Nerve Stimulation (ONS) for Migraine: OPTIMISE

Bone Mineral Density in Women With Uterine Fibroids or Endometriosis

Spinal Cord Stimulation With Precision® System Versus Reoperation for Failed Back Surgery Syndrome

A Study of the Efficacy and Safety of JZP-258 in Subjects With Narcolepsy With Cataplexy

A Phase 2 Study to Evaluate the Safety and Efficacy of Intravenously Administered Benralizumab (MEDI-563).

Quality of Life in Patients With Congenital Afibrinogenemia

Dose-finding Study of GLPG0634 as add-on to Methotrexate in Active Rheumatoid Arthritis Participants (DARWIN1)

Sleep Apnea in TIA/Stroke: Reducing Cardiovascular Risk With Positive Airway Pressure

GreenLight XPS Laser System Retrospective Chart Review

Efficacy and Safety of PL9643 Ophthalmic Solution in Subjects With Dry Eye

Exploring the Optimal Duration of a Group-based Online Behavioral Weight Loss Program