Clinical Trials in Philadelphia

Showing 761-780 of 20,904 trials

Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)

NCT06385483

This phase II MATCH treatment trial tests how well afatinib works in treating patients with cancer that has certain genetic changes. Afatinib is in a class of medications called kinase inhibitors. It is used in patients whose cancer has a certain mutation (change) in the EGFR gene. It works by blocking the action of mutated EGFR that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Advanced LymphomaAdvanced Malignant Solid NeoplasmRefractory Lymphoma+2 more

National Cancer Institute (NCI)19 participantsStarted Feb 2018

Philadelphia, Pennsylvania, United States

RECRUITINGPhase 3< 1 mile

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

NCT04852887

This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.

Stage I Breast Cancer

NRG Oncology1,670 participantsStarted Jun 2021

Birmingham, Alabama, United States • Mobile, Alabama, United States • Kingman, Arizona, United States +829 more locations

Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

Find Trials by Condition in Philadelphia

Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

Depemokimab Asthma Imaging and Bronchoscopy Sub-Study

Evaluation of the Efficacy and Safety of LevoCept

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Galvanize Prospective/Retrospective Pulsed Electric Field Device Registry

A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia

A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)

A Real-World Evidence Study Evaluating the Effects of the Human Optimization Project Protocol on Methylation Biomarkers and Health-Related Quality of Life in Women

Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma

FOG-001 in Locally Advanced or Metastatic Solid Tumors

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

A Study of BMS-986504 in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion (MountainTAP-9)

A Phase 2a Multicenter Clinical Trial of TB006 in Participants With Parkinson's Disease

A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System