Clinical Trials in Philadelphia

Showing 6681-6700 of 15,860 trials

Expanded Access to Voxelotor for Patients With Sickle Cell Disease Who Have No Alternative Treatment Options

NCT03943615

The intent of this open-label, multicenter expanded access program (EAP) is to provide early access to voxelotor prior to market authorization

Sickle Cell Disease

Pfizer

Birmingham, Alabama, United States • Mobile, Alabama, United States • Atlanta, Georgia, United States +15 more locations

COMPLETEDNA< 1 mile

Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions

NCT01092416

This is a prospective, single-arm, multi-center study to evaluate the safety and performance of the OAS in treating de novo, severely calcified coronary lesions in adult subjects. Study is going to enroll up to 429 subjects in up to 50 U.S. study sites. The primary safety endpoint is 30-day MACE and primary efficacy endpoint is procedural success. All subjects will be treated with the orbital atherectomy system and adjunctive stent. All subjects will be followed in clinic at 30 days. Additionally, all subjects will have an annual phone call or clinical follow up at each anniversary until study is closed.

Coronary Artery Disease

Abbott Medical Devices443 participantsStarted May 2010

Birmingham, Alabama, United States • Montgomery, Alabama, United States • Gilbert, Arizona, United States +48 more locations

Expanded Access to Voxelotor for Patients With Sickle Cell Disease Who Have No Alternative Treatment Options

Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions

Find Trials by Condition in Philadelphia

Comparative Study to Evaluate Efficacy and Safety of Gepotidacin to Nitrofurantoin in Treatment of Uncomplicated Urinary Tract Infection (UTI)

Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLC

Relapse Prevention Study in Patients With Schizophrenia

PDGeneration: Mapping the Future of Parkinson's Disease

A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH)

ProduceRx: Improving Weight and Cardiovascular Risk in Adults With Food Insecurity and Obesity

An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)

Study to Assess the Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia Patients

Simple Bone Cysts in Kids

Safety and Performance of Journey II XR Total Knee System

Multi-center Prospective Study to Evaluate Outcomes of the Moderate to Severely Calcified Coronary Lesions (MACE)

A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression

Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease

Pharmacokinetics, Efficacy and Safety of Abatacept Administered Subcutaneously (SC) in Children and Adolescents With Active Polyarticular Juvenile Idiopathic Arthritis (pJIA) and Inadequate Response (IR) to Biologic or Non Biologic Disease Modifying Anti-rheumatic Drugs (DMARDs)

A Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma

Study on the Effectiveness and Safety of the Combination of the Two Drugs Regorafenib and Nivolumab in Patients With Colorectal Cancer (Cancer of the Colon or Rectum Classified as Proficient Mismatch Repair and Microsatellite Stable)

A Safety and Tolerability Study of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness.

Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-modifying Antirheumatic Drug (DMARDs) and/or Janus Kinase (JAK) Inhibitors