Clinical Trials in Philadelphia

Showing 6561-6580 of 20,904 trials

EEG to Monitor Propofol Anesthetic Depth in Infants and Toddlers

NCT05701748

The goal of this study is monitor anesthetic depth of children undergoing propofol anesthesia using electroencephalography (EEG). The main questions it aims to answer are: 1. EEG spectral edge frequency (SEF95) readings where 50% of patients do not respond to three stimuli. 2. The propofol blood concentration that corresponds to each of the three EEG SEF95 readings Participants will undergo EEG monitoring, stimuli (placement of oral pacifier, electrical stimulation, and laryngoscopy), and blood collection.

Electroencephalography Spectral Edge FrequencyAnesthetic Depth

Children's Hospital of Philadelphia100 participantsStarted Feb 2023

Philadelphia, Pennsylvania, United States

COMPLETEDPhase 1< 1 mile

A Dose Finding Study of ZW49 in Patients With HER2-Positive Cancers

NCT03821233

This is a first-in-human, Phase 1, multicenter, open-label, dose-escalation study to establish the maximum-tolerated dose (MTD) or recommended dosage (RD) of ZW49, the investigational agent under study, and to assess the safety and tolerability of ZW49. Eligible patients include those with locally advanced (unresectable) or metastatic HER2-expressing cancers.

HER2-expressing Cancers

Zymeworks BC Inc.112 participantsStarted Apr 2019

Duarte, California, United States • Tampa, Florida, United States • Chicago, Illinois, United States +13 more locations

EEG to Monitor Propofol Anesthetic Depth in Infants and Toddlers

A Dose Finding Study of ZW49 in Patients With HER2-Positive Cancers

Find Trials by Condition in Philadelphia

PerQseal® Clinical Study

Study of the Safety and Efficacy of MR-100A-01 in Approximately 1200 Healthy Women for up to 13 Cycles

The PROMISE Study: Duavee in Women With DCIS

A Study to Evaluate Molnupiravir (MK-4482; MOV) in Participants With Severe Renal Impairment (MK-4482-003)

A Study to Evaluate Molnupiravir (MK-4482) in Participants With Moderate Hepatic Impairment (MK-4482-016)

Cash Transfers to Address Child Welfare Involvement

Impact of Menstrual Phase on Oral Glucose Sensitivity

Study of a New Technique for Imaging Pancreatic Cancer

PhII ICb With/Without Erbitux in MBC Pts

Technology Development for Noninvasive Prenatal Genetic Diagnosis Using Whole Fetal Cells From Maternal Peripheral Blood

The CorCinch - Functional Mitral Valve Regurgitation (FMR) Study

A 12-Week Placebo-Controlled Study to Investigate the Efficacy, Safety, and Tolerability of RO7017773 in Participants Aged 15-45 Years With Autism Spectrum Disorder (ASD)

Efficacy, Safety and Tolerability of the Combination of Tropifexor & Licogliflozin and Each Monotherapy, Compared With Placebo in Adult Patients With NASH and Liver Fibrosis.

Trilaciclib in Patients Receiving Sacituzumab Govitecan-hziy for Triple Negative Breast Cancer

Coordinated, Collaborative, Comprehensive, Family-based, Integrated, Technology-enabled Stroke Care

Prospective Research in Infants With Mild Encephalopathy

RGX-121 Gene Therapy in Children 5 Years of Age and Over With MPS II (Hunter Syndrome)

PMCF Study on the Safety, Performance and Clinical Benefits Data of the ToggleLoc™ 2.9mm in the Elbow