Clinical Trials in Philadelphia

Showing 6481-6500 of 15,860 trials

PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC

NCT06062602

This is a multi-center, open-label Phase 0 substudy designed to study the localized pharmacodynamics (PD) of TAK-676 alone or in combination with Carboplatin, 5-FU, or Paclitaxel within the tumor microenvironment (TME) when administered intratumorally in microdose quantities via the CIVO device in patients diagnosed with Head and Neck Squamous Cell Carcinoma presenting with a surface accessible solid tumor for which there is a scheduled surgical intervention. This substudy is a cohort of the PBI-MST-01 Master Protocol.

Head and Neck Squamous Cell Carcinoma

Presage Biosciences15 participantsStarted Jul 2021

Shreveport, Louisiana, United States • The Bronx, New York, United States • Cincinnati, Ohio, United States +1 more locations

TERMINATEDNA< 1 mile

Pediatric REPlAcement of the PulmonaRy ValvE in Tetralogy of Fallot -

NCT03634072

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect with the vast majority of survivors of corrective surgery left with some degree of right ventricular (RV) volume overload due to pulmonary regurgitation (PR) which cause RV enlargement with right heart failure, diminished biventricular function, ventricular arrhythmia, sudden death and decreased exercise performance over time. Pulmonary valve replacement (PVR) has been thought to ameliorate these complications but the timing of replacement has yet to be determined with equipoise at the moment in this decision making process. As nearly all studies in this regard are retrospective with much less data in pediatric TOF than adults, this pilot trial sets the stage to create a prospective randomized trial in the teenage years.

Tetralogy of Fallot

Children's Hospital of Philadelphia1 participantsStarted Jul 2018

Washington D.C., District of Columbia, United States • Atlanta, Georgia, United States • Chicago, Illinois, United States +3 more locations

PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC

Pediatric REPlAcement of the PulmonaRy ValvE in Tetralogy of Fallot -

Find Trials by Condition in Philadelphia

The Impact of Dyad Exercises on Well-being and Connection in Young Adults

Base-in Prism Spectacles for Intermittent Exotropia

MEDI9447(Oleclumab) Pancreatic Chemotherapy Combination Study.

Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma

Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome

Equitable Implementation of Cascade Screening for Familial Hypercholesterolemia

Ecopipam Tablets to Study Tourette's Syndrome in Children and Adolescents

A Phase 3 Study of Solosec® for the Treatment of Trichomoniasis

Treatment of Pain Associated With Lumbosacral Radiculopathy in Adults

Timing of Inguinal Hernia Repair in Premature Infants

A Study to Evaluate TRS01 Eye Drops in Participants With Active Non-infectious Anterior Uveitis

Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease

Addressing Intimate Partner Violence Among Women Veterans

An Study to Evaluate the Safety and Efficacy of Copanlisib in Combination With Nivolumab in Patients With Advanced Solid Tumors

Comparison Across Multiple Types of Sleep Deprivation

An Extension Study to Evaluate the Long-Term Safety and Tolerability of UTTR1147A in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease

A Study of AND017 to Treat Anemia in Non-dialysis-Dependent Chronic Kidney Disease (NDD-CKD) Patients

Telomere Associated Variables (TAVs) in Prostate Cancer