Clinical Trials in Philadelphia

Showing 5281-5300 of 15,860 trials

Functional Lung Imaging With DECT and 4DCT

NCT04702607

The basic premise of this pilot study is to enroll 40 patients over 3 years who have Stage II, III, or IV non-small cell lung cancer and are planned for definitive treatment with concurrent chemoradiation where a contrast enhanced 4DCT is planned.

Non Small Cell Lung Cancer

Abramson Cancer Center at Penn Medicine40 participantsStarted Jan 2021

Philadelphia, Pennsylvania, United States

COMPLETEDPhase 4< 1 mile

Nasal Spray Study in Sjogren's Dry Eye Disease

NCT05700422

This study will investigate how well OC-01 (varenicline) nasal spray can treat the signs and symptoms of dry eye disease in those Sjogren's Syndrome. Patients at least 18 years old with moderate-to-severe Sjogren's dry eye disease may be eligible for this study. If you are eligible to participate in the study and you decide to join, there will be 3 study visits over approximately 1 month. You will also self-administer the nasal spray at home every day, 2 times a day during this month.

Sjogren's SyndromeDry Eye

University of Pennsylvania39 participantsStarted May 2023

Philadelphia, Pennsylvania, United States

COMPLETEDPhase 2< 1 mile

Pembrolizumab + Radiation for Locally Adv SCC of the Head and Neck (SCCHN) Not Eligible Cisplatin

NCT02609503

This study is being done to evaluate the efficacy of Pembrolizumab, concomitant with and following standard of care definitive radiation, for locally advanced squamous cell carcinoma of the head and neck patients who are not good candidates for Cisplatin.

Head and Neck Cancer

UNC Lineberger Comprehensive Cancer Center29 participantsStarted May 2016

Baltimore, Maryland, United States • Chapel Hill, North Carolina, United States • Philadelphia, Pennsylvania, United States

Functional Lung Imaging With DECT and 4DCT

Nasal Spray Study in Sjogren's Dry Eye Disease

Pembrolizumab + Radiation for Locally Adv SCC of the Head and Neck (SCCHN) Not Eligible Cisplatin

Find Trials by Condition in Philadelphia

Memory Retrieval and Encoding Investigated by Neural Stimulation

Temozolomide (TMZ) in Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

Preemie Hypothermia for Neonatal Encephalopathy

A Study of Escalating Doses of ASG-22CE Given as Monotherapy in Subjects With Metastatic Urothelial Cancer and Other Malignant Solid Tumors That Express Nectin-4

Open-label, Clinical Study to Evaluate the Safety and Tolerability of TreT in Subjects With PAH Currently Using Tyvaso

Entyvio (Vedolizumab) Long Term Safety Study

Long Term Follow Up of Sub-retinal Transplantation of hESC Derived RPE Cells in Stargardt Macular Dystrophy Patients

A Study of ASP1951 in Subjects With Advanced Solid Tumors

Dose Escalation Trial of Endoluminal High-Dose-Rate Brachytherapy With Concurrent Chemotherapy for Rectal or Anal Cancer in Patients With Recurrent Disease or Undergoing Non-Operative Management

Induction Optimization With Stelara for Crohn's Disease

A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors

Phase 1 Trial of LVGN6051 as Single Agent and in Combination With Keytruda (Pembrolizumab) in Advanced or Metastatic Malignancy

Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1

A Dose Escalation and Expansion Study of ASP4132 to Subjects With Advanced Refractory Tumors and Lymphoma

A Study to Investigate How Effective and Safe Solifenacin Succinate Suspension is in Treating Children/Adolescents Aged 5 to Less Than 18 Years With Symptoms of Overactive Bladder (OAB) Compared to a Non-active Drug

Vaginal Photobiomodulation for Chronic Pelvic Pain

Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.