Clinical Trials in Philadelphia

Showing 3821-3840 of 15,860 trials

Genetics of Insulin and Incretins in Cystic Fibrosis

NCT01852448

Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.

Cystic Fibrosis

Children's Hospital of Philadelphia550 participantsStarted May 2013

Philadelphia, Pennsylvania, United States • Philadelphia, Pennsylvania, United States

RECRUITINGNA< 1 mile

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

NCT05237258

This research study is evaluating whether primary palliative care is an alternative strategy to specialty palliative care for improving quality of life, symptoms, mood, coping, and end of life outcomes in patients with acute myeloid leukemia (AML).

Relapsed Adult AMLPrimary Refractory Acute Myeloid LeukemiaHigh Risk Acute Myeloid Leukemia

Massachusetts General Hospital2,300 participantsStarted Jun 2022

Birmingham, Alabama, United States • Stanford, California, United States • Denver, Colorado, United States +17 more locations

Genetics of Insulin and Incretins in Cystic Fibrosis

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

Find Trials by Condition in Philadelphia

Reducing Challenging Behaviors in Children With Autism Through Digital Health

Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis

PaTH Clinical Data Research Network (CDRN) Idiopathic Pulmonary Fibrosis (IPF) Clinician Patient Partnership Cohort

Group Coaching Study for Life Goals

Study to Evaluate the Safety & Immunogenicity of IMNN-101 Administered in Healthy Adults Previously Vaccinated Against SARS-CoV-2

Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies

A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED

SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)

Motivational Refinements for Facilitating Reinforcement Schedule Thinning

iTBS for Alcohol Use Disorder

This Study Will Collect Clinical and Patient Reported Experience Data From Participants Requiring Urine Output Management Overnight in the Home Setting.

International CIPN Assessment and Validation Study

A Study of LY2784544 in Participants With Myeloproliferative Neoplasms

Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp

Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis

A Study of Nivolumab and Ipilimumab in Untreated Participants With Stage 3 Non-small Cell Lung Cancer (NSCLC) That is Unable or Not Planned to be Removed by Surgery

A First-in-human Study of Multiple Doses of BB-1701 in Subjects With Locally Advanced/Metastatic HER2 Expressing Solid Tumors

A Post-Market Study for Long-Term Effectiveness and Safety of the NTX100 for RLS