Clinical Trials in Philadelphia

Showing 3101-3120 of 9,968 trials

A Study to Evaluate Molnupiravir (MK-4482; MOV) in Participants With Severe Renal Impairment (MK-4482-003)

NCT05386758

This purpose of this study is to evaluate the plasma pharmacokinetics (PK) of N-hydroxycytidine (NHC), the nucleoside metabolite of molnupiravir, after a single oral dose of 800 mg molnupiravir in participants with severe renal impairment compared to healthy mean matched control participants. This study will also assess the safety and tolerability of molnupiravir in participants with severe renal impairment and the urinary excretion of NHC after a single oral dose of 800 mg molnupiravir in participants with severe renal impairment compared to healthy mean matched control participants. The primary hypothesis is that the plasma PK participants with severe renal impairment will be similar to that observed in the healthy mean matched control participants.

Renal Impairment

Merck Sharp & Dohme LLC16 participantsStarted Jun 2022

Hallandale, Florida, United States • Miami, Florida, United States • Tampa, Florida, United States +1 more locations

COMPLETEDPhase 3< 1 mile

Study of the Safety and Efficacy of MR-100A-01 in Approximately 1200 Healthy Women for up to 13 Cycles

NCT05139121

Study of the contraceptive efficacy, cycle control, safety, and tolerability of MR-100A-01 in approxmiately 1200 women for up to 13 cycles

Contraception

Mylan Technologies Inc.1,319 participantsStarted Oct 2021

Mobile, Alabama, United States • Mobile, Alabama, United States • Mesa, Arizona, United States +97 more locations

A Study to Evaluate Molnupiravir (MK-4482; MOV) in Participants With Severe Renal Impairment (MK-4482-003)

Study of the Safety and Efficacy of MR-100A-01 in Approximately 1200 Healthy Women for up to 13 Cycles

Find Trials by Condition in Philadelphia

Cognitive Behavioral Therapy and Light Therapy

Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)

Chronic Insomnia and CSF Markers of Dementia

Study of Nerve Repair and Reconstruction Associated With Major Extremity Trauma

Building Employment Skills Through Therapy for Veterans

Intermediate-Size Expanded Access Protocol (EAP) for LP352

Novel Experimental COVID-19 Therapies Affecting Host Response

A Clinical Study To Assess The Safety And Effectiveness Of The OMNI® Surgical System

Inolitazone Dihydrochloride and Paclitaxel in Treating Patients With Advanced Anaplastic Thyroid Cancer

Basic and Applied Research on Extinction Bursts

Intermediate Expanded Access Protocol CNMAu8.EAP04

Trial of LAVA-051 in Patients with Relapsed/refractory CLL, MM, or AML

Safety and Clinical Activity of KT-253 in Adult Patients with High Grade Myeloid Malignancies, Acute Lymphocytic Leukemia, Lymphoma, Solid Tumors

Trastuzumab Deruxtecan With Nivolumab in Advanced Breast and Urothelial Cancer

A Study of Elecsys® Troponin T hs Gen 6 in Participants With Symptoms of Acute Coronary Syndrome

Study of Mavrilimumab (KPL-301) in Participants Hospitalized With Severe Corona Virus Disease 2019 (COVID-19) Pneumonia and Hyper-inflammation

Extension to the MAGNIFY MS Trial on Mavenclad® (Magnify MS Extension)

International Treatment-extension Study in Adult Participants With Multiple Myeloma and Who Have Derived Clinical Benefit From Isatuximab