Clinical Trials in Philadelphia

Showing 2901-2920 of 9,968 trials

MOv19-BBz CAR T Cells in aFR Expressing Recurrent High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

NCT03585764

Phase I study to establish safety and feasibility of intraperitoneally administered lentiviral transduced MOv19-BBz CAR T cells with or without cyclophosphamide + fludarabine as lymphodepleting chemotherapy

Ovarian CancerFallopian Tube CancerPrimary Peritoneal Carcinoma

University of Pennsylvania46 participantsStarted Oct 2018

Philadelphia, Pennsylvania, United States

RECRUITINGPhase 1/2< 1 mile

PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

NCT06721689

The phase 1 primary objective is to determine the pediatric recommended phase 2 dose (RP2D) of PEEL-224 as a single agent (phase 1A) and in combination with vincristine and temozolomide (phase 1B). The phase 2 primary objective is to estimate the objective response rate (ORR) in children with refractory, progressive and relapsed NBL and rhabdomyosarcoma (RMS) treated with the RP2D of PEEL-224 in combination with vincristine and temozolomide.

Refractory Solid TumorsRelapsed Solid TumorsRelapsed Neuroblastoma+3 more

Theodore Laetsch59 participantsStarted Mar 2025

Philadelphia, Pennsylvania, United States

Enrolling By InvitationPhase 2/3< 1 mile

Effects of Ketone Supplementation on Acute Alcohol Withdrawal

NCT06173973

The goal of this study is to study the effects of the ketone supplement Kenetik compared to placebo (an inactive beverage) on alcohol withdrawal symptoms during the 5 days of clinical alcohol withdrawal management treatment at the Caron Treatment Center.

Alcohol Use DisorderAlcohol WithdrawalAlcohol Dependence+1 more

University of Pennsylvania50 participantsStarted Mar 2024

Philadelphia, Pennsylvania, United States • Wernersville, Pennsylvania, United States

MOv19-BBz CAR T Cells in aFR Expressing Recurrent High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

Effects of Ketone Supplementation on Acute Alcohol Withdrawal

Find Trials by Condition in Philadelphia

Safety and Efficacy of the SurVeil™ Drug-Coated Balloon

A Trial of Pembrolizumab in Combination With Chemotherapy and Radiotherapy in Stage III NSCLC (KEYNOTE-799, MK-3475-799)

A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis

Paricalcitol Plus Gemcitabine and Nab-paclitaxel in Metastatic Pancreatic Cancer

NOVOCART®3D for Treatment of Articular Cartilage of the Knee

ALTTO (Adjuvant Lapatinib And/Or Trastuzumab Treatment Optimisation) Study; BIG 2-06/N063D

A Study to Evaluate the Efficacy and Safety of OTX-TIC (Travoprost) Intracameral Implant for Patients With Open-angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Optimal Post Tpa-Iv Monitoring in Ischemic Stroke

Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients

Efficacy and Safety Study of Narsoplimab in Pediatric Patients With High-Risk Hematopoietic Stem Cell Transplant TMA

Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049)

A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC

A Study of LY3473329 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events

A Prospective Observational Study of TPIAT

Safety and Efficacy of BHV-3000 (Rimegepant) Orally Disintegrating Tablet for the Acute Treatment of Chronic Rhinosinusitis

First-in-human Single Agent Study of SAR442257 in RRMM and RR-NHL

Study to Investigate Hepatic Impairment on PK, Safety, Tolerability of Camizestrant in Post-Menopausal Female Subjects