Clinical Trials in Philadelphia

Showing 2781-2800 of 9,968 trials

Risk Assessment of Carotid Plaques Using 3D Contrast-Enhanced Ultrasound

NCT04643431

This is an open-label, non-randomized study conducted at Thomas Jefferson University comparing pressure-gradient estimates (obtained between a carotid plaque and the carotid artery) to imaging and histology markers of plaque vulnerability. There is an inverse relationship between the subharmonic signal magnitude from contrast-enhanced ultrasound microbubbles and ambient pressure. This pressure estimation technique (referred as SHAPE) will be used to estimate the pressure gradient across the carotid plaque cap noninvasively in vivo.

Carotid Atherosclerosis

Thomas Jefferson University20 participantsStarted Dec 2020

Philadelphia, Pennsylvania, United States

COMPLETEDPhase 1< 1 mile

A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

NCT03260322

The primary purpose of this study is to evaluate the tolerability and safety profile of ASP8374 when administered as a single agent and in combination with pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumor malignancies. Also primary purpose is to characterize the pharmacokinetic profile of ASP8374 when administered as a single agent and in combination with pembrolizumab. Last primary purpose of this study is to determine the recommended Phase 2 dose (RP2D) of ASP8374 when administered as a single agent and in combination with pembrolizumab. The secondary purpose of this study is to evaluate the anti-tumor effect (objective response rate \[ORR\], duration of response \[DOR\], persistence of response after discontinuation, and disease control rate \[DCR\]) of ASP8374 when administered as a single agent and in combination with pembrolizumab. NTP: Neutropenia NHAE:Non-haematological AE GBS: Guillain-Barré syndrome"" IRR: Infusion-related reaction AST: Aspartate aminotransferase ALT: Alanine aminotransferase MS/MG: Myasthenia Syndrome/Myasthenia Gravis TRT: Treatment-related Toxicity TCP: Thrombocytopenia

Advanced Solid Tumors

Astellas Pharma Global Development, Inc.169 participantsStarted Sep 2017

Scottsdale, Arizona, United States • Los Angeles, California, United States • Los Angeles, California, United States +51 more locations

Risk Assessment of Carotid Plaques Using 3D Contrast-Enhanced Ultrasound

A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Find Trials by Condition in Philadelphia

Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT)

Post-trial Access Program of Idursulfase-IT Along With Elaprase in Children With Hunter Syndrome

Leveraging Telepsychology and Behavioral Economics to Increase Fidelity to CBT

Inclusion Appeal Videos and Intent to Register for Pediatric Clinical Trials

A Study To Evaluate The Effect Of A Supratherapeutic Dose Of MK-8189 On The QTc Interval In Participants With Schizophrenia (MK-8189-019)

Ph 2 Study of the Safety and Efficacy of Three HU6 Dose Levels and Placebo in Nonalcoholic Steatohepatitis

Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Cancer

Treatment of Persistent Atrial Fibrillation With Sphere-9 Catheter and Affera Mapping and Ablation System

A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002)

A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optical Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma

Long-term Follow-up Study With Darvadstrocel in the Treatment of Complex Perianal Fistula

Study of REM-422 in Patients With AML or Higher Risk MDS

Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant

Clinical Trial Readiness to Solve Barriers to Drug Development in FSHD

FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

Cataract Surgery in Conjunction With Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients With Mild to Moderate Primary Open-Angle Glaucoma

Phase 2b Study of MBS2320 in Participants With Methotrexate-Refractory RA