Clinical Trials in Pennsylvania

Showing 17981-18000 of 19,675 trials

A Randomized Double Blind Placebo Controlled Study of the Effect of Swallowed Beclomethasone Dipropionate on Inflammatory Markers in Adult Patients With Eosinophilic Esophagitis

NCT01016223

The investigators hypothesize that swallowed beclomethasone leads not only to improvement of symptoms and decreased number of eosinophils in esophageal mucosa, but also to a decrease in other markers of tissue inflammation like mast cells, CD4+ T lymphocytes, IL4, IL-5, IL13, GM-CSF and TGF-beta as well as serum ultra-sensitive C-Reactive Protein (CRP). The investigators aim to characterize the response of esophageal inflammation to swallowed topical glucocorticoids, and identify biomarkers to assess response to treatment. This research will elucidate the effect of treatment with beclomethasone on various inflammatory markers in EoE, which is currently not well-understood. This work will explore the pathophysiology of EoE, and has the potential to find a non-invasive biomarker such as high-sensitivity CRP that can be used to monitor the response to treatment.

Eosinophilic Esophagitis

Penn State University20 participantsStarted Mar 2010

Hershey, Pennsylvania, United States

COMPLETED56 miles

An Observational Study to Assess Respiratory Syncytial Virus (RSV) Respiratory Events Among Premature Infants

NCT00983606

The primary objective is to assess the burden of respiratory disease in outpatient settings among 32 to 35 weeks' gestational age (wGA) infants in the USA who did not receive RSV prophylaxis during the infants' first RSV season.

Healthy

MedImmune LLC3,000 participantsStarted Sep 2009

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Dothan, Alabama, United States +219 more locations

A Randomized Double Blind Placebo Controlled Study of the Effect of Swallowed Beclomethasone Dipropionate on Inflammatory Markers in Adult Patients With Eosinophilic Esophagitis

An Observational Study to Assess Respiratory Syncytial Virus (RSV) Respiratory Events Among Premature Infants

Find Trials by Condition in Pennsylvania

Ramelteon in Adults With Chronic Insomnia

Fibromyalgia Health Outcome Study on Cost of Treatments

A Study to Assess the Safety and Effect of TC-5214 in Patients With Major Depressive Disorder.

A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2)

Study to Evaluate the Safety and Efficacy of the Renal Assist Device in Patients With Acute Renal Failure

A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1)

Study to Evaluate Two Formulations of Carisoprodol in Subjects With Musculoskeletal Spasm of the Lower Back

A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder

FS VH S/D 500 S-apr in Vascular Surgery

Antimicrobial PK in Infants With Suspected or Confirmed Infection

Zonisamide SR Plus Bupropion SR Combination Therapy in Subjects With Obesity

Efficacy, Safety, Tolerability of Neramexane in Patients With Subjective Tinnitus

Fibrin Sealant Vascular Surgery Study

A Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS)

Olanzapine Given in Combination With Zonisamide SR to Prevent Weight Gain in Schizophrenic Subjects

A Study to Evaluate the Safety and the Effects of Risperidone Compared With Other Atypical Antipsychotic Drugs on the Growth and Sexual Maturation in Children

Safety and Tolerability of QVA149 (Indacaterol/Glycopyrrolate) Compared to Placebo and to Indacaterol in Patients With Moderate to Severe Stable Chronic Obstructive Pulmonary Disease (COPD)

Evaluate Efficacy, Safety and Tolerability of AZD1656 as Add-on Treatment to Metformin in Type 2 Diabetes Mellitus (TD2M) Patients