Clinical Trials in North Carolina

Showing 11401-11420 of 20,428 trials

A Study of Ruxolitinib in Combination With Nilotinib in Patients With Chronic Phase CML

NCT02973711

This study combines two drugs (ruxolitinib and the tyrosine kinase inhibitor, nilotinib) in an attempt to eliminate the CML (Chronic Myeloid Leukemia) stem cell population and thus allow for the deepest and most durable response possible in patients with CML in chronic phase who have achieved a complete hematologic remission (CHR), complete cytogenetic remission (CCyR), and major molecular remission (MMR), but not a complete molecular remission (CMR). The study will look at safety and tolerability of ruxolitinib when combined with nilotinib in a phase I study and will help establish the MTD (Maximum Tolerated Dose) of ruxolitinib when combined with nilotinib. Once the optimal dose of ruxolitinib is established in the phase I setting, a phase II evaluation will seek to establish the efficacy of this combination.

Leukemia, Chronic Myeloid

University of Michigan Rogel Cancer CenterStarted Jan 2018

Ann Arbor, Michigan, United States • Winston-Salem, North Carolina, United States

COMPLETEDPhase 341 miles

Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance

NCT00991276

The purpose of this study is to assess the efficacy and safety of pregabalin and pramipexole versus placebo in the treatment of restless legs syndrome and associated sleep disturbance.

Restless Legs Syndrome

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.85 participantsStarted Dec 2009

Jasper, Alabama, United States • Phoenix, Arizona, United States • Tucson, Arizona, United States +38 more locations

A Study of Ruxolitinib in Combination With Nilotinib in Patients With Chronic Phase CML

Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance

Find Trials by Condition in North Carolina

Diagnosis and Monitoring of Eosinophilic Esophagitis Using the Cytosponge

Model 4396 Left Ventricular (LV) Lead Chronic Performance Study

A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma

Exploratory Safety Study of ALD518 in Subjects With Steroid-refractory Acute Graft Versus Host Disease (GVHD)

Efficacy and Safety of Pazopanib Monotherapy After First Line Chemotherapy in Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Monitoring in Dialysis -- a Prospective, Multi-center, Single-arm, Non-randomized, Observational Study in Patients Who Are Undergoing Hemodialysis.

A STUDY OF A RSV VACCINE WHEN GIVEN TOGETHER WITH TDAP IN HEALTHY NONPREGNANT WOMEN AGED BETWEEN 18 TO 49 YEARS

Pasireotide & Everolimus in Adult Patients With Radioiodine-Refractory Differentiated & Medullary Thyroid Cancer

A Study Evaluating ABI-H0731 as Adjunctive Therapy in Participants With Chronic Hepatitis B Infection

A Study to Assess the Safety and Tolerability of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA).

A Study of ONCO-DOX in Locally Advanced Hepatocellular Carcinoma

Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial

A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)

Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation

Multicenter Bone and Joint Health Study

Tipifarnib and Combination Chemotherapy in Treating Patients With Stage II or Stage III Breast Cancer

A Proof of Concept Study of GSK3640254 in Human Immunodeficiency Virus-1 (HIV-1) Infected Treatment-naive Adults

AIR Extension Study - Long-Term Safety of Alair Treated Subjects