Clinical Trials in North Carolina

Showing 2321-2340 of 9,731 trials

rTMS for Stimulant Use Disorders

NCT04907357

The purpose of the study is to determine feasibility of repetitive transcranial magnetic stimulation (rTMS) for individuals with moderate to severe cocaine or methamphetamine use disorder (CUD/MUD). Potential participants will be age 18-65, and interested in cutting down or stopping use. Participants will be randomized to one of two groups; groups will receive rTMS or sham rTMS (placebo) over the course of an 8-week treatment period, and complete follow-up assessments at the end of treatment, 12, and 16 weeks post-randomization.

Cocaine Use DisorderMethamphetamine AbuseCocaine Dependence+6 more

Medical University of South Carolina129 participantsStarted Feb 2022

Winston-Salem, North Carolina, United States • Charleston, South Carolina, United States • Dallas, Texas, United States +1 more locations

COMPLETEDPhase 341 miles

Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 1)

NCT04410978

Primary Objective: To assess efficacy of daily SAR442168 compared to a daily dose of 14 mg teriflunomide (Aubagio) measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS Secondary Objective: To assess efficacy of SAR442168 compared to teriflunomide (Aubagio) on disability progression, MRI lesions, cognitive performance and quality of life To evaluate the safety and tolerability of daily SAR442168 To evaluate population pharmacokinetics (PK) of SAR442168 and relevant metabolites and its relationship to efficacy and safety To evaluate pharmacodynamics (PD) of SAR442168

Relapsing Multiple Sclerosis

Sanofi974 participantsStarted Jun 2020

Birmingham, Alabama, United States • San Francisco, California, United States • Aurora, Colorado, United States +176 more locations

rTMS for Stimulant Use Disorders

Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 1)

Find Trials by Condition in North Carolina

Vaginal Ecosystem and Network in the United States Study

A Study of EDP-938 in Non-hospitalized Adults With RSV Who Are at High Risk for Complications.

Overcoming Barriers to the Uptake of Cascade Screening for Lynch Syndrome: Workbook Feasibility Study

DAYBREAK: A Study of Setmelanotide in Participants With Specific Gene Variants in the Melanocortin-4 Receptor (MC4R) Pathway

Pertuzumab and Trastuzumab as Neoadjuvant Treatment in Patients With HER2-Positive Breast Cancer

A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration

Long-Term Follow-up of Gene Therapy for APOE4 Homozygote Alzheimer's Disease

STEM-PD Open Label Extension (OLE)

Study Testing Response Effect of KY1005 Against Moderate-to-Severe Atopic Dermatitis, The STREAM-AD Study

Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules

TTX-030 Single Agent and in Combination With Immunotherapy or Chemotherapy for Patients With Advanced Cancers

A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma

A Study to Evaluate ASP0367 in Participants With Primary Mitochondrial Myopathy

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

Human Amniotic Membrane On Venous Leg Ulcers In an Elderly Population

This Study Will Collect Clinical and Patient Reported Satisfaction Data From Males Requiring Urine Output Management Overnight in the Home Setting.

Perioperative Therapy for Resectable and Borderline-Resectable Pancreatic Adenocarcinoma With Molecular Correlates

Predicting Local and Distant Recurrence in T1 Colorectal Cancer