Clinical Trials in New York

Showing 6701-6720 of 17,259 trials

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

NCT04264143

The blood brain barrier (BBB) prevents some drugs from successfully reaching the target source. Convection-Enhanced Delivery (CED) is a method of direct infusion of drugs under controlled pressure to the tumor that may reduce systemic side effects of drugs in the patient. The purpose of this Phase I study is to find the maximum tolerated dose of MTX110 (a water-soluble Panobinostat nanoparticle formulation) and Gadolinium that can be given safely in children with newly diagnosed diffuse midline gliomas. All patients enrolled in the study will receive infusion of MTX110 and Gadolinium delivered with a pump directly into the tumor over 9-11 days.

Diffuse Intrinsic Pontine GliomaDiffuse Pontine and Thalamic GliomasDiffuse Midline Glioma

Luca Szalontay9 participantsStarted Mar 2020

New York, New York, United States

TERMINATEDPhase 1/2< 1 mile

A Parallel Arm Phase 1b/2a Study of DKN-01 as Monotherapy or in Combination With Docetaxel for the Treatment of Advanced Prostate Cancer With Elevated DKK1

NCT03837353

This is a non-randomized multi-center Phase 1b/2a dose escalation and dose expansion study testing DKN-01 as monotherapy or in combination with docetaxel in metastatic castration-resistant prostate cancer. Patients need to be biomarker positive (Dickkopf-1 \[DKK1\]) either in plasma or biopsy. Other biopsies for correlative studies are encouraged but not mandatory. Pharmacokinetic (PK) testing of one pre-treatment blood sample and one post-treatment blood sample will be mandatory on Day 1 of every cycle.

Prostate Cancer

NYU Langone Health18 participantsStarted Apr 2019

San Francisco, California, United States • Baltimore, Maryland, United States • St Louis, Missouri, United States +2 more locations

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

A Parallel Arm Phase 1b/2a Study of DKN-01 as Monotherapy or in Combination With Docetaxel for the Treatment of Advanced Prostate Cancer With Elevated DKK1

Find Trials by Condition in New York

Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease

Risk Communication in African American Smokers

A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression

A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury

SMART GOALS for Youth With Prediabetes

Sorafenib Tosylate Following a Liver Transplant in Treating Patients With Liver Cancer

Phase II Trial of Combination Immunotherapy With NeuVax and Trastuzumab in High-risk HER2+ Breast Cancer Patients

Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant

Process-instructed Self Neuro-Modulation (PRISM) for Attention Deficit/ Hyperactivity Disorder - Adults

A Trial of a New Magnetic Breast Marking Clip

We Care About Brooklyn - A Digital Behavioral Intervention to Optimize Engagement in Maternal Healthcare

iCanCope With Sickle Cell Pain

Double-blind Study to Evaluate the Safety and Efficacy of Antroquinonol in Mild-Moderate COVID-19 Hospitalized Patients

Adaptive RadioTherapy for OroPharynx Cancer

Maximal Usage Pharmacokinetics and Safety of ARQ-151 in Children With Plaque Psoriasis (ARQ-151-215)

A Study Evaluating the Safety, Tolerability, and Effect on Microvascular Obstruction of Intravenous Temanogrel in Adult Participants Undergoing Percutaneous Coronary Intervention

Survival Prolongation by Rationale Innovative Genomics

Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in Subjects With Solid Tumours Expressing Neurotensin Receptor Type 1.