Clinical Trials in Nashville

Showing 12861-12880 of 17,403 trials

Phase 1 Study of Oprozomib Administered Orally in Patients With Advanced Refractory or Recurrent Solid Tumors

NCT01129349

To evaluate the safety and tolerability of Oprozomib in patients with advanced refractory or recurrent solid tumors including determination of its Dose Limiting Toxicity (DLT) and Maximum Tolerated Dose (MTD) To determine the pharmacokinetics (PK) of Oprozomib To explore the anti-tumor activity of Oprozomib in this patient population including the overall response rate (ORR), the duration of responses (DOR), the progression-free survival (PFS) and time to progression (TTP) To define the pharmacodynamics (PDn) of Oprozomib.

Solid Tumors

Amgen44 participantsStarted Apr 2010

Scottsdale, Arizona, United States • Nashville, Tennessee, United States • San Antonio, Texas, United States

COMPLETEDPhase 1< 1 mile

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Multiple Myeloma and Renal Disease

NCT01949532

The purpose of this study is to see how the body and the cancer react to carfilzomib, including measuring the amount of the study drug in the blood at certain times following dosing. This study is being done in people with normal kidney function and those with end-stage renal disease to see if they respond differently to the study drug.

Relapsed Multiple MyelomaEnd-stage Renal Disease

Amgen26 participantsStarted Jan 2014

Detroit, Michigan, United States • Lake Success, New York, United States • Canton, Ohio, United States +10 more locations

Phase 1 Study of Oprozomib Administered Orally in Patients With Advanced Refractory or Recurrent Solid Tumors

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Multiple Myeloma and Renal Disease

Find Trials by Condition in Nashville

Urinary Prostaglandin E Metabolite (PGE-M), A Metabolite of Prostaglandin E2 (PGE2): A Novel Biomarker of Crohn's Disease Activity

Discovery Elbow Long-Term Survivorship

Impact of Dietary Intervention on Weight Change in Subjects With Type 2 Diabetes

Mucosal Impedance in Pediatric Population

Safety and Pharmacology Study of SNX-5422 in Subjects With Refractory Hematological Malignancies

PREventative Study Against URate-lowering Drug-induced Gout Exacerbations 1

Characterization of Dermal Reactions in Pediatric Patients With ADHD Using DAYTRANA

Phase 2 Study of Carfilzomib in Relapsed Multiple Myeloma

A Study To Investigate Safety And Efficacy Of CP-690,550 For Induction Therapy In Subjects With Moderate To Severe Crohn's Disease

Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure

Inhibitor Development in Patients With Hemophilia A Undergoing Surgery

Atorvastatin (Lipitor) Therapy in Patients With Clinically Isolated Syndrome (CIS) at Risk for Multiple Sclerosis

Study to Evaluate the Efficacy, Safety and Pharmacokinetics of PT001, PT003, and PT005 Following Chronic Dosing (7 Days) in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)

Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis

Gamma Vacuum Foil (GVF) Versus Cross-linked Polyethylene in Total Knee Arthroplasty Study

Effects of Dapagliflozin on Insulin Resistance and Insulin Secretion in Subjects With Type 2 Diabetes

Effect of Squalamine Lactate Ophthalmic Solution, 0.2% in Subjects With Neovascular Age-Related Macular Degeneration

Pulsed Radiofrequency Energy to Treat Post-Bunionectomy Pain