Clinical Trials in Nashville

Showing 7681-7700 of 15,379 trials

Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer

NCT02820961

The purpose of this study is to determine the effect of exemestane on the pharmacokinetics (PK) of entinostat and to determine the effect of entinostat on the PK of exemestane in patients with locally recurrent or metastatic estrogen receptor positive (ER+) breast cancer. Additionally, this study will evaluate the safety and tolerability of entinostat in combination with exemestane, and assess the effectiveness of entinostat in combination with exemestane in terms of best overall response and overall survival.

Breast CancerEstrogen Receptor Positive Breast Cancer

Syndax Pharmaceuticals61 participantsStarted Jun 2016

Denver, Colorado, United States • Sarasota, Florida, United States • Nashville, Tennessee, United States

COMPLETEDPhase 2< 1 mile

Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study)

NCT03452397

The objective of this study is to evaluate the safety and effectiveness of OC-02 Nasal Spray as compared to placebo on signs and symptoms of dry eye disease.

Dry Eye Disease

Oyster Point Pharma, Inc.165 participantsStarted Feb 2018

Louisville, Kentucky, United States • Andover, Massachusetts, United States • Nashville, Tennessee, United States

COMPLETEDPhase 2< 1 mile

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

NCT00308516

This phase II trial will investigate the combination of adjuvant 5-fluorouracil, radiation, and bevacizumab in patients with stage II and III rectal cancer, followed by FOLFOX6 and bevacizumab. Fluorouracil (FU) has proven to be an effective and safe regimen in the treatment of stage II and III rectal cancer. Recent evidence has proven fluorouracil/leucovorin (FL) in combination with bevacizumab is superior to FL alone and when combined with irinotecan is superior to (irinotecan plus fluorouracil/leucovorin (IFL) alone. This trial will be one of the first clinical trials to evaluate a combination of targeted therapy, radiation, and chemotherapy in the adjuvant treatment of a common solid tumor.

Rectal CancerCancer of the RectumColorectal Cancer

SCRI Development Innovations, LLC66 participantsStarted Mar 2006

Anniston, Alabama, United States • Jonesboro, Arkansas, United States • Fort Myers, Florida, United States +11 more locations

Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer

Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study)

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

Find Trials by Condition in Nashville

Stem Cell Transplant With Lenalidomide Maintenance in Patients With Multiple Myeloma (BMT CTN 0702)

Assessment of LBR-101 In Chronic Migraine

Study of INCB053914 in Subjects With Advanced Malignancies

An Extension Study to Evaluate the Long-term Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria

Preoperative Chemotherapy and Bevacizumab in Patients With Stage IB (>4 cm), II, or Select Stage III NSCLC

The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Participants With Advanced Solid Tumors

Comparison of Two Bronchodilator Inhalers in Pediatric Asthmatics

A Study of Obinutuzumab in Combination With Idasanutlin and Venetoclax in Participants With Relapsed or Refractory (R/R) Follicular Lymphoma (FL) or Rituximab in Combination With Idasanutlin and Venetoclax in Participants With R/R Diffuse Large B-Cell Lymphoma (DLBCL)

Restore EF Observational Study

Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy

A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)

Randomized Endo-Vein Graft Prospective

Inhibiting Fatty Acid Synthase to Improve Efficacy of Neoadjuvant Chemotherapy

A Study of Gantenerumab in Participants With Prodromal Alzheimer's Disease

Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids

Study of CAD-9303 in Subjects With Schizophrenia

PREMOD2 With Near Infrared Spectroscopy Sub-study