Clinical Trials in Massachusetts

Showing 7821-7840 of 13,570 trials

Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

NCT00135005

This study is an open-label, multicenter, Phase I dose-escalation study of the combination of AMN107 and imatinib (STI571) in patients with imatinib-resistant GIST. This study is designed to determine the Phase II dose of AMN107 and imatinib when administered together in patients with imatinib-resistant GIST, and to characterize the safety, tolerability and pharmacokinetic (PK) profile of this combination.

Gastrointestinal Stromal Tumors

Novartis Pharmaceuticals59 participantsStarted Aug 2005

Boston, Massachusetts, United States • Philadelphia, Pennsylvania, United States • Lyon, France +2 more locations

COMPLETEDPhase 226 miles

Residual Effects of Intoxication on Student Performance

NCT00183170

The primary goal of the study is to assess the residual effects of heavy drinking on academic performance. The investigators will also explore whether these effects differ by family history of alcohol abuse and hangover symptoms, as well as compare males and females with respect to these effects. The primary hypothesis is that intoxication (0.10 g% blood alcohol concentration \[BAC\]) with an alcoholic beverage impairs next-day academic performance, as measured by scores on quizzes, standardized academic achievement tests, and standardized neurobehavioral assessments. The secondary hypothesis is that family-history-positive individuals will show a greater performance decrement the day after heavy drinking than family-history-negative individuals.

Alcoholic IntoxicationNeurobehavioral Manifestations

Boston University239 participantsStarted Feb 2004

Boston, Massachusetts, United States

Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)

Residual Effects of Intoxication on Student Performance

Find Trials by Condition in Massachusetts

Use of Intrapyloric Botulinum Injections in Children

A Phase 2 Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of PF-06252616 in Duchenne Muscular Dystrophy

Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation

Study of Epratuzumab Versus Placebo in Subjects With Moderate to Severe General Systemic Lupus Erythematosus (SLE)

Efficacy, Safety, and Pharmacokinetics of Brachial Plexus Block With EXPAREL in Shoulder Surgery

Follow-up of the PEPITES Study to Evaluate Long-term Efficacy and Safety of Viaskin Peanut in Children

Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655)

Fluid Responsiveness Evaluation in Sepsis-associated Hypotension

A Study Evaluating the Safety and Efficacy of Topical BPR277 for the Treatment of Atopic Dermatitis and Netherton Syndrome

The Assessment of Copper Parameters in Wilson Disease Participants on Standard of Care Treatment

Safety and Efficacy of Exenatide as Monotherapy and Adjunctive Therapy to Oral Antidiabetic Agents in Adolescents With Type 2 Diabetes

Safety and Effectiveness of Cartiva Implant in the Treatment of First CMC Joint Osteoarthritis Compared to LRTI (GRIP 2)

Spinal Cord Injury in the Pediatric Population - an International Multicenter Study

A Study of HSP990 Administered by Mouth in Adult Patients With Advanced Solid Tumors

Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)

Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib

Combination of AUY922 With Trastuzumab in HER2+ Advanced Breast Cancer Patients Previously Treated With Trastuzumab

Masitinib in the Treatment of Patients With Severe Uncontrolled Asthma and Elevated Eosinophil Levels