Novel Use of Restasis and PROSE Devices

Inclusion Criteria

• •1. Written Informed Consent has been obtained prior to any study-related procedures taking place
• •2. Subject is Male or Female, 18 years of age or older prior to the initial visit
• •3. Is an established wearer of PROSE devices for \> 6 months in both eyes
• •4. Has a finalized PROSE lens design in both eyes, in the opinion of the clinician
• •5. The PROSE design does NOT include fenestrations
• •6. Subject requires PROSE devices to treat symptoms and/or signs from underlying dry eye disease, GVHD, Sjogren's syndrome, limbal stem cell deficiency, keratoconjunctivitis sicca, or ocular surface disease
• •7. Baseline Corneal staining grade of 2 or higher in total, both eyes combined (NEI Grading System)
• •8. Baseline Ocular Surface Disease Index 13 or greater
• •9. In the opinion of the investigator, the subject can follow study instructions
• •10. In the opinion of the investigator, the subject can complete all study procedures and visits
• •11. Able to wear PROSE device continuously for at least 6 hours at a time without removal, in each eye
• •12. Able to wear PROSE device for at least 10 total hours a day, in each eye
• •13. Able to wear PROSE device in subsequent continuous sessions of 6 hours, followed by a break to re-instill Restasis in device bowl, followed by another period of continuous wear of at least 4 hours
• •14. Currently using buffered preservative free normal saline (Purilens) in the device bowl or willing to transition to buffered preservative free normal saline (Purilens) use in the device bowl during the study