Clinical Trials in Massachusetts

Showing 4901-4920 of 13,570 trials

Exploration of Blood Flow Regulation to Bone in Humans

NCT04083794

Without blood flow, bone cannot maintain its integrity. Bone blood flow responds to various local and systemic factors, however, bone perfusion in humans remains relatively unstudied. The investigators will study key mechanisms that regulate bone perfusion in able-bodied and contrast responses to those with spinal cord injury (SCI). SCI is a model of chronic reduced loading with loss of sympathetic regulation. In tibial cortical bone, the investigators will: 1) determine the impact of compressive loading with and without muscle contractions; 2) determine the impact of vascular sympathetic activity and systemic perfusion pressure; 3) compare the response between able-bodied and those with SCI. Acute metabolic needs of bone due to loading increase flow substantially. In addition, the bone vasculature is innervated by a rich network of sympathetic nerves that serve a functional purpose in the control of blood flow. A critical limitation to the study of bone blood flow in humans has been the lack of non-invasive assessments. Previously, the investigators developed a near infrared spectroscopy (NIRS) device to non-invasively assess blood content in bone and assessed tibial perfusion in response to exercise. Here, the investigators will test the hypothesis that bone blood flow increases proportional to loading conditions in both able-bodied individuals and those with SCI. The investigators will also test the hypothesis that there are decreases in blood bone flow that are proportional to increases in leg vascular sympathetic outflow in the able-bodied, but that changes in bone blood flow are proportional to changes in blood pressure in those with SCI. The proposed research will be some of the first to determine the control of bone flow in humans.

Bone Blood Flow Regulation

Spaulding Rehabilitation Hospital90 participantsStarted May 2018

Cambridge, Massachusetts, United States

TERMINATEDPhase 326 miles

A Study to Evaluate LB1148 for Return of Bowel Function in Subjects Undergoing Bowel Resection

NCT05470387

The purpose of this study is to evaluate the safety and efficacy of LB1148 in subjects undergoing planned bowel resection.

IleusGastro-Intestinal Disorder

Palisade Bio23 participantsStarted Jun 2022

Mobile, Alabama, United States • La Jolla, California, United States • Orange, California, United States +20 more locations

Exploration of Blood Flow Regulation to Bone in Humans

A Study to Evaluate LB1148 for Return of Bowel Function in Subjects Undergoing Bowel Resection

Find Trials by Condition in Massachusetts

Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

rRp450-Phase I Trial in Liver Metastases and Primary Liver Tumors

Long-term Follow-Up Study of RGX-314 and Fellow Eye Substudy

Phase 2 Spectra Study to Evaluate the Safety and Efficacy of OPL-0401 in Patients With Diabetic Retinopathy

Investigating Gains in Neurocognition in an Intervention Trial of Exercise

Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations

Phase I Study of Cell Therapies for the Treatment of Patients With Relapsed or Refractory AML or High-risk MDS

Category Learning Retention in Adults With and Without Developmental Language Disorder

Tradipitant in Treatment-resistant Pruritus Associated With Atopic Dermatitis

Study of ADCT-301 in Patients With Selected Advanced Solid Tumors

Isatuximab in Combination With Cemiplimab in Relapsed/Refractory Multiple Myeloma (RRMM) Patients

Study to Demonstrate the Efficacy, Safety and Tolerability of an Intravenous Regimen of Secukinumab Compared to Placebo in Subjects With Active axSpA

A Study of TAK-981 Given With Rituximab in Adults With Relapsed or Refractory CD20-Positive Non-Hodgkin Lymphoma

Effects of Dapagliflozin in Non-diabetic Patients With Proteinuria

A Study of Replagal in Treatment-naïve Adults With Fabry Disease

Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Patients With Breast Cancer

Study of Efficacy and Safety of Ligelizumab in Adolescents and Adults With Chronic Inducible Urticaria Who Remain Symptomatic Despite Treatment With H1- Antihistamines

Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome