Clinical Trials in Massachusetts

Showing 4281-4300 of 13,570 trials

Prophylactic vs Therapeutic Cerebrospinal Fluid Drain Placement During Endovascular Thoracoabdominal Aortic Aneurysm Repair

NCT04941157

This is a pilot study to be performed at the University of Alabama at Birmingham (UAB) and the University of Massachusetts to determine the feasibility and develop the processes for a future randomized controlled trial to evaluate the occurrence of spinal cord ischemia after endovascular thoracoabdominal aneurysm repair using prophylactic cerebrospinal fluid drains versus no pre-emptive drain. The research question to be addressed is as follows: In the setting of a comprehensive spinal cord ischemia prevention protocol, do prophylactic CSF drains decrease the rate of spinal cord ischemia (SCI) in patients undergoing endovascular thoracoabdominal aneurysm repair?

Spinal Cord Ischemia

University of Alabama at Birmingham20 participantsStarted Oct 2022

Birmingham, Alabama, United States • Worcester, Massachusetts, United States

COMPLETEDPhase 218 miles

A Study of TAK-861 in Participants With Narcolepsy Type 2

NCT05687916

The main aim is to evaluate the effect of TAK-861 on symptoms of narcolepsy, including excessive daytime sleepiness (EDS) as measured by sleep latency from the Maintenance of Wakefulness Test (MWT). The study will enroll approximately 60 participants and they will be randomly assigned to 3 groups (20 per group) to take one of two different doses of TAK-861 or a placebo. All the participants will receive the treatment for 8 weeks. Participants will be asked to complete some questionnaires during the study. This trial will be conducted in North America, Europe, and Asia Pacific.

Narcolepsy Type 2

Takeda71 participantsStarted Jan 2023

Birmingham, Alabama, United States • Scottsdale, Arizona, United States • Redwood City, California, United States +53 more locations

Prophylactic vs Therapeutic Cerebrospinal Fluid Drain Placement During Endovascular Thoracoabdominal Aortic Aneurysm Repair

A Study of TAK-861 in Participants With Narcolepsy Type 2

Find Trials by Condition in Massachusetts

Evaluate the Efficacy and Safety of ACP-044 in Subjects With Pain Associated With Osteoarthritis of the Knee

Comparison of Various Prosthetic Foot-Ankle Mechanisms

Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People At Risk for Alzheimer's Disease

Effects of Auditory Stimulation on Sleep and Memory in Schizophrenia

Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection

Nemaline Myopathy Clinical Research Network (NM-CTRN)

Testing Cabozantinib, Crizotinib, Savolitinib and Sunitinib in Kidney Cancer Which Has Progressed

A Study Evaluating the Safety and Efficacy of BEAM-201 in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LL)

Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma

Contrast Enhanced Spectral Mammography vs. MRI for Breast Cancer Screening

Ketamine for the Treatment for Alcohol Use Disorder in the ED

Benefits of µCor in Ambulatory Decompensated Heart Failure

Open-Label Extension Study of Upadacitinib in Adult Participants With Moderate to Severe Atopic Dermatitis

Emergency Department-Initiated Buprenorphine Validation Network Trial

A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response

Safety, Tolerability, and Pharmacokinetics of Clesrovimab (MK-1654) in Infants (MK-1654-002)

Computer-based Intervention for Alcohol-using HIV/HCV+ Women

Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors