HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patients

Exclusion Criteria

• •1. History of factor IX inhibitors
• •2. Positive factor IX inhibitor test at screening
• •3. Select screening laboratory value \>2 times upper limit of normal
• •4. Positive human immunodeficiency virus (HIV) test at screening, not controlled with anti-viral therapy
• •5. Active infection with hepatitis B or C virus at screening
• •6. History of Hepatitis B or C exposure, currently controlled by antiviral therapy at the end of the lead-in phase
• •7. Previous gene therapy treatment
• •8. Receipt of an experimental agent within 60 days prior to screening
• •9. Current participation or anticipated participation within one year after study drug administration in this trial in any other interventional clinical trial involving drugs or devices