Clinical Trials in Massachusetts

Showing 4201-4220 of 15,316 trials

A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)

NCT03835819

This research study is studying a drug combination as a possible treatment for endometrial cancer. The drugs involved in this study are: * mirvetuximab soravtansine (IMGN853) * pembrolizumab

Endometrial Cancer

Dana-Farber Cancer Institute18 participantsStarted Jan 2020

Boston, Massachusetts, United States • Worcester, Massachusetts, United States • Lake Success, New York, United States

COMPLETEDPhase 126 miles

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

NCT05759949

This is a Phase 1, first-in-human, open-label study designed to evaluate the maximum tolerated dose (MTD), recommended phase 2 dose (RP2D), safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of RLY-5836 in advanced solid tumors in participants harboring a PIK3CA mutation in blood and/or tumor per local assessment. The study consists of 2 parts, a dose escalation (Part 1) and a dose expansion (Part 2).

PIK3CA MutationSolid Tumor, AdultHER2-negative Breast Cancer+5 more

Relay Therapeutics, Inc.41 participantsStarted Mar 2023

Orlando, Florida, United States • Indianapolis, Indiana, United States • Boston, Massachusetts, United States +4 more locations

A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

Find Trials by Condition in Massachusetts

Telehealth Exercise and Mindfulness for Pain in Osteoarthritis - Stage 1B

Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs

A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRD

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

This Study Tests Whether BI 409306 Prevents Patients With a Specific Type of Mental Illness (Attenuated Psychosis Syndrome) From Becoming Worse. This Study Looks at How Well Patients Tolerate the Medicine and How Effective it is Over 1 Year

Neurobiology of Functional Movement Disorder and Non-Epileptic Seizures

Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)

A Study of IMR-687 in Adult Participants With Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia)

A Study of IMR-687 in Subjects With Sickle Cell Disease

Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults With Chronic Kidney Disease

The Dragon PLC Trial (DRAGON-PLC)

Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

A Study of Long-term Effect of Dupilumab on Skin Barrier Function in Pediatric Participants With Atopic Dermatitis

Dose-Ranging Study of ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy in Subjects With Fabry Disease (STAAR)

REC 0/0559 Eye Drops for Treatment of Moderate and Severe Neurotrophic Keratitis in Adult Patients

A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam in Early Manifest Huntington's Disease

Pulmonary Embolism International THrOmbolysis Study-3

Natural Sunlight Protection and Simulated Sunlight Protection Offered by Sunscreens and Fabrics