Clinical Trials in Massachusetts

Showing 4141-4160 of 15,316 trials

Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder

NCT03526354

The proposed study is a 4-site, 12-week, novel, feasibility, investigation of patients who have co-occurring diagnoses of schizophrenia and current substance use disorder (alcohol, cocaine, heroin, or cannabis). Thirty-nine participants will be randomly assigned to switch to brexpiprazole (the brexpiprazole group) or remain on the same antipsychotic treatment (the control group). The study will be conducted at 4 sites in the US. The investigators expect to enroll 80 subjects across 3 sites. UMass Medical School, Worcester MA is the lead site. Sub-sites include Massachusetts General Hospital (MGH) and the University of North Carolina at Chapel Hill (UNC).

SchizophreniaSchizoaffective DisorderSubstance Use Disorders

University of Massachusetts, Worcester50 participantsStarted Jun 2018

Augusta, Georgia, United States • Boston, Massachusetts, United States • Worcester, Massachusetts, United States +1 more locations

COMPLETEDPhase 225 miles

Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery

NCT03188393

This phase II trial studies how well biopsy of breast after chemotherapy works in predicting pathologic response in patients with stage II-IIIA breast cancer undergoing breast conserving surgery. Tumor tissue collected from biopsy before surgery may help to check if chemotherapy destroyed the breast cancer cells and may be compared to the tumor removed during surgery to check if they are the same.

Invasive Breast CarcinomaStage II Breast CancerStage IIA Breast Cancer+2 more

NRG Oncology105 participantsStarted Apr 2017

Birmingham, Alabama, United States • Mobile, Alabama, United States • Phoenix, Arizona, United States +378 more locations

Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder

Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery

Find Trials by Condition in Massachusetts

Effects of Low FODMAP Diet on Leaky Gut

Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

Soy Nuts and Cardiovascular Risk in Postmenopausal Women

A Personalized Neoantigen Cancer Vaccine in Treatment Naïve, Asymptomatic Patients With IGHV Unmutated CLL.

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

Intervening in Food Insecurity to Reduce and Mitigate (InFoRM) Childhood Obesity

Multi-Component Breath Alcohol Intervention

ThRombectomy In Mild Ischemic Stroke With a Visible Intracranial veSsel Occlusion

Efficacy, Safety and Pharmacokinetics of Rilzabrutinib in Patients With Warm Autoimmune Hemolytic Anemia (wAIHA)

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-901 in Participants With Selected Advanced Solid Tumors

REGENETEN™ Bioinductive Implant System in Full-thickness Tears

Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis

Study of Durvalumab in Combination With Platinum and Etoposide for the First Line Treatment of Patients With Extensive-stage Small Cell Lung Cancer

A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying Degree of Impaired Renal Function

A RCT Evaluating the Clinical Benefit of a Silver Dressing in the Treatment of Venous Leg Ulcers

Prospective Natural History Study of Retinitis Pigmentosa

A Study of Mipasetamab Uzoptirine (ADCT-601) in Participants With Solid Tumors

DETOUR I Clinical Study for Percutaneous Femoropopliteal Bypass