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Active Not RecruitingNANCT04285398

Prospective Natural History Study of Retinitis Pigmentosa

This is natural history study of rods and cones degenerations in patients with Retinitis Pigmentosa (RP) caused by pathogenic mutations in RHO, PDE6a or PDE6b gene mutations.

Lead sponsor: SparingVision•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

SparingVision

This is an open, longitudinal, prospective, multicentric study to describe the disease progression in patients with retinitis pigmentosa due to mutation in genes with selective expression in rods: rhodopsin (RHO), phosphodiesterase 6a (PDE6a) or phosphodiesterase 6b (PDE6b).RHO,PDE6A or PDE6B mutation.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•RP with mutations affecting the RHO, PDE6A and PDE6B genes
•Visual acuity ≥ 20/200 for at least one eye at inclusion visit
•Binocular Visual field diameter ≥ 5° as measured on the Goldmann III-4e isopter at inclusion visit
•Patients having signed the informed consent form
•Sufficient knowledge of the local language to ensure understanding of the tasks to be performed and the instructions received
•Patient affiliated to a Health Security System if they are included in a clinical site based in France (per law)

Exclusion Criteria

•Patients with any other gene mutation known to be involved in RP
•Patients with other ocular disorder likely to impact the retinal function
•Pregnant or breastfeeding women

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 22, 2025Terms

Trial snapshot

StatusACTIVE_NOT_RECRUITING

PhaseNA

Enrollment82

Start dateFeb 2020

Last updatedMay 22, 2025

Condition

Retinitis Pigmentosa

Locations shown

UPMC Eye Center

Pittsburgh, Pennsylvania

CHNO XV-XX Paris - CIC 1423

Paris

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 22, 2025Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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