Clinical Trials in Massachusetts

Showing 3621-3640 of 8,511 trials

PNT2258 for Treatment of Patients With Richter's Transformation (Brighton)

NCT02378038

This study is sponsored by Sierra Oncology, Inc. formerly ProNAi Therapeutics, Inc. It is a multi-center, single-arm, 2-stage, open-label phase II investigation of PNT2258 to characterize anti-tumor activity and collect safety data on patients with Richter's Transformation.

Richter's Transformation

Sierra Oncology LLC - a GSK company5 participantsStarted Aug 2015

Orange, California, United States • Chicago, Illinois, United States • Boston, Massachusetts, United States +6 more locations

COMPLETEDPhase 326 miles

Evaluation of ELX/TEZ/IVA in Cystic Fibrosis (CF) Subjects 2 Through 5 Years

NCT04537793

This study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of elexacaftor (ELX)/tezacaftor (TEZ)/ivacaftor (IVA) triple combination therapy in CF subjects 2 through 5 years of age.

Cystic Fibrosis

Vertex Pharmaceuticals Incorporated83 participantsStarted Nov 2020

Tucson, Arizona, United States • Palo Alto, California, United States • Aurora, Colorado, United States +19 more locations

PNT2258 for Treatment of Patients With Richter's Transformation (Brighton)

Evaluation of ELX/TEZ/IVA in Cystic Fibrosis (CF) Subjects 2 Through 5 Years

Find Trials by Condition in Massachusetts

A Phase 3 Lot to Lot Consistency Study of Live Oral Cholera Vaccine, PXVX0200 in Healthy Adults

A Phase II Study of Epstein-Barr Virus-Specific Immunotherapy for Nasopharyngeal Carcinoma

Reduced-Intensity Regimen Before Donor Bone Marrow Transplant in Treating Patients With Myelodysplastic Syndromes

The TIME-2b Study: A Study of AKB-9778 (Razuprotafib), a Novel Tie 2 Activator, in Patients With Non-Proliferative Diabetic Retinopathy (NPDR)

Rosiglitazone in Treating Patients With Liposarcoma

Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAE

A Study to Evaluate Safety, Tolerability, and Distribution of a Microdose of Radiolabeled BIIB067 (99mTc-MAG3-BIIB067) Co-administered With BIIB067 (Tofersen) to Healthy Adults

Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lymphocytic Leukemia

High-Dose Melphalan Plus Peripheral Stem Cell Transplantation in Treating Patients With Primary Systemic Amyloidosis

Combination Chemotherapy After Surgery in Treating Patients With Cancer of the Esophagus or Stomach

The Navigator Trial

Mucin Levels in Dry Eye and Normal Populations

Methotrexate Compared With Paclitaxel in Treating Patients With Advanced Head and Neck Cancer

Study of Adjunctive Ganaxolone Treatment in Female Children With Protocadherin 19 (PCDH19)-Related Epilepsy (Violet Study)

Study of Verinurad in Heart Failure With Preserved Ejection Fraction

A Study of the Burden of Illness and Treatment Patterns in Teenagers and Adults With Hereditary Angioedema

Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection

A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19