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A Long-term Follow-up Study of Subjects With Malignancies Treated With CRISPR CAR T Cellular Therapies
This study will evaluate the long-term safety and efficacy of CRISPR CAR T cellular therapies
All subjects with hematological and solid malignancies who are enrolled in a parent study and were exposed to allogeneic CRISPR CAR T cellular therapy will be asked to participate in this long-term follow-up (LTFU) study. Subjects who have completed the parent study for the protocol-defined duration, or who have discontinued the parent study early, or who are in secondary follow-up (follow up of subjects with progressive disease or who receive a subsequent line of anticancer therapy) in the parent study may enroll in this LTFU study. This will allow for collection of long-term efficacy data (as applicable) and safety data up to 15 years post-treatment with CRISPR CAR T cellular therapies.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
City of Hope
Duarte, California, United States
Cedars Sinai
Los Angeles, California, United States
Stanford
Stanford, California, United States
Yale New Haven Hospital
New Haven, Connecticut, United States
Emory
Atlanta, Georgia, United States
University of Chicago
Chicago, Illinois, United States
University of Kansas
Westwood, Kansas, United States
University of Minnesota
Minneapolis, Minnesota, United States
Washington University Saint Louis
St Louis, Missouri, United States
MSKCC
New York, New York, United States
Start Date
November 22, 2023
Primary Completion Date
August 1, 2038
Completion Date
August 1, 2038
Last Updated
August 14, 2025
70
ESTIMATED participants
Non Interventional
OTHER
Lead Sponsor
CRISPR Therapeutics AG
NCT05529069
NCT07257419
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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