Clinical Trials in Massachusetts

Showing 3061-3080 of 15,316 trials

Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression

NCT05630963

This study looks at the role of the Nociceptin/Orphanin FQ receptor system in the brain of individuals with current or past major depressive disorder (MDD). It also examines how individuals with a history of depression make certain decisions and which brain regions are involved in such decisions. Information collected through MRI, PET, biospecimens (i.e., blood, saliva) and behavioral tasks will be used to predict depressive symptoms in the future.

Major Depressive Disorder

Mclean Hospital228 participantsStarted Dec 2021

Belmont, Massachusetts, United States

Active Not RecruitingPhase 326 miles

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

NCT05468489

This is a randomized, open-label study of Serplulimab plus chemotherapy (Carboplatin-Etoposide) in comparison with Atezolizumab plus chemotherapy in previously untreated US patients with ES-SCLC. Subjects in this study will be randomized to arm A or B at 1:1 ratio as follows: * Arm A (Serplulimab): Serplulimab + chemotherapy (carboplatin-etoposide) * Arm B (control): Atezolizumab + chemotherapy (carboplatin-etoposide)

Extensive Stage Small Cell Lung Cancer

Shanghai Henlius Biotech200 participantsStarted Nov 2022

Birmingham, Alabama, United States • Goodyear, Arizona, United States • Tucson, Arizona, United States +64 more locations

Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

Find Trials by Condition in Massachusetts

Extension Study to Evaluate Safety and Efficacy of CTP-543 in Adults With Alopecia Areata

OCT Guided Trans Nasal Imaging of the Small Intestine in Adults

A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease

CNAP vs IABP in Pregnant Women With Placenta Accreta

Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

Study to Investigate Genetic Causes of Severe Early Childhood Onset Obesity.

Financial Incentives for Homeless Smokers: A Community-based RCT

Study of RP-3500, Camonsertib, in Advanced Solid Tumors

Trial of Indication-Based Transfusion of Red Blood Cells in ECMO

Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)

Effect of tDCS Timing on Safety Memory in PTSD

Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies

A Study of Sotorasib (AMG 510) in Participants With Stage IV NSCLC Whose Tumors Harbor a KRAS p.G12C Mutation in Need of First-line Treatment

Study of Daxdilimab (HZN-7734) in Participants With Moderate-to-Severe Primary Discoid Lupus Erythematosus

GRAVITAS-119: Itacitinib in Combination With Calcineurin Inhibitor-Based Interventions for the Prophylaxis of Graft-Versus Host Disease

A Study of ZW171 in Participants With Advanced or Metastatic Mesothelin-expressing Cancers

Study of VIR-2218, VIR-3434, and/or PEG-IFNα in Subjects With Chronic Hepatitis B Virus Infection

Azacitidine Combined With Pembrolizumab and Epacadostat in Subjects With Advanced Solid Tumors (ECHO-206)