Clinical Trials in Massachusetts

Showing 2861-2880 of 8,511 trials

PREventing Pain After Surgery

NCT05306665

The present study aims to adapt and modify a brief presurgical Acceptance and Commitment Therapy (ACT) intervention aimed at preventing the transition to Chronic Post-Surgical Pain (CPSP) and reducing long-term opioid use. Investigators will then assess the acceptability, feasibility, and preliminary efficacy of the finalized intervention to prevent the transition to CPSP and reduce post-surgical opioid use six months following lumbar spine surgery. Finally, investigators will identify psychosocial and psychophysical phenotypes associated with response to this intervention.

Pain, BackSpinal StenosisDisc Herniation+3 more

Brigham and Women's Hospital140 participantsStarted Jan 2023

Chestnut Hill, Massachusetts, United States

Active Not RecruitingPhase 1/226 miles

Durvalumab and Tremelimumab for Pediatric Malignancies

NCT03837899

The purpose of the study is to determine the recommended dose of durvalumab and tremelimumab (immunotherapy drugs) in pediatric patients with advanced solid and hematological cancers and expand in a second phase to test the efficacy of these drugs once this dose is determined.

Pediatric CancerSolid Tumor PediatricHematological Malignancies

AstraZeneca50 participantsStarted Mar 2019

Baltimore, Maryland, United States • Boston, Massachusetts, United States • New Hyde Park, New York, United States +16 more locations

PREventing Pain After Surgery

Durvalumab and Tremelimumab for Pediatric Malignancies

Find Trials by Condition in Massachusetts

Tegaderm Vs. Transpore for Eye Protection During Anesthesia

The PRISM Intervention for Adolescents and Young Adults Receiving Hematopoietic Cell Transplantation

Covid-19 Infection and Pulmonary Distress Treatment With Zanubrutinib in Hospitalized Participants

A Study to Evaluate the Safety of Long-term Ivacaftor Treatment in Participants With Cystic Fibrosis Who Are Less Than 24 Months of Age at Treatment Initiation and Have an Approved Ivacaftor-Responsive Mutation

A Study of Olaratumab (LY3012207) Plus Pembrolizumab in Participants With Advanced or Metastatic Soft Tissue Sarcoma

Investigation of Clot in Ischemic Stroke and Hematoma Evacuation

Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases

TriVerity in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis

Vitamin D to Improve Outcomes by Leveraging Early Treatment: Long-term Brain Outcomes in Vitamin D Deficient Patients

Cytomegalovirus (CMV) Vaccine in Donors and Recipients Undergoing Allogeneic Hematopoietic Cell Transplant (HCT)

tDCS to Decrease Opioid Relapse (UG3)

Rhode Island Asthma Integrated Response Program

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Pneumococcal Vaccine-experienced Adults (V116-006, STRIDE-6)

A Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Doublet Chemotherapy

Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Neutralizing Antibody BGB-DXP593 in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)

A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma

Study of BGB-A317 in Participants With Relapsed or Refractory Mature T- and NK-cell Neoplasms