Clinical Trials in Maryland

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Idebenone for Primary Progressive Multiple Sclerosis

NCT01854359

Background: \- The Idebenone in Patients With Primary Progressive Multiple Sclerosis (IPPoMS) trial tested a new drug for multiple sclerosis. In the IPPoMS trial, participants took either idebenone or placebo. Researchers want to give idebenone to all participants for 1 year. It is still not certain whether idebenone can slow the progression of multiple sclerosis, but this study may help answer that question. Objectives: * To provide idebenone to all participants on the IPPoMS trial. * To collect data on the safety and effectiveness of idebenone for primary progressive multiple sclerosis. Eligibility: \- Individuals at least 18 years of age who have completed 3 years in the IPPoMS trial. Design: * The first study visit for this trial will happen on the same day as the last visit for the IPPoMS trial. * Participants will provide a blood samples and will have a lumbar puncture. They will also receive a new supply of idebenone to take three times a day with food. They will keep a diary to report on any side effects. * After this first treatment visit, participants will have two follow-up visits to the NIH 6 months apart. These visits may be scheduled over multiple days. Participants will provide blood and urine samples. They will also have imaging studies of the brain and spine. * Participants will have phone calls with the study researchers to provide updates on their condition and any side effects.

Multiple SclerosisPrimary Progressive Multiple Sclerosis

National Institute of Allergy and Infectious Diseases (NIAID)61 participantsStarted Mar 2013

Bethesda, Maryland, United States

UNKNOWNNA17 miles

Reducing Concurrent Opioid-Benzodiazepine Prescriptions

NCT03887247

The purpose of this effort is to use informative e-mails to improve the process of prescribing of opioids and benzodiazepines within the National Capital Region/Military Health System (NCR/MHS), with the aim of decreasing concurrent opioid and benzodiazepine prescribing.

Adverse Drug Effect of OpioidsAdverse Drug Effect of Benzodiazepines

Walter Reed National Military Medical Center2,234 participantsStarted Jun 2019

Bethesda, Maryland, United States

Idebenone for Primary Progressive Multiple Sclerosis

Reducing Concurrent Opioid-Benzodiazepine Prescriptions

Find Trials by Condition in Maryland

Uphold LITE Post-Market Surveillance Study

A Phase II Study to Evaluate the Efficacy of IdeS to Desensitize Transplant Patients With a Positive Crossmatch Test

Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility

Gemcitabine/Taxotere/Xeloda (GTX) With Cisplatin in Subjects With Metastatic Pancreatic Cancer

Study to Determine the Safety, Tolerability, and Efficacy of Evenamide in Patients With Chronic Schizophrenia

Phase 3 Study to Evaluate the Efficacy & Safety of Self-Administered Injections of BMN165 by Adults With PKU

Impact of Pre-transplant Anti-fibrotic Therapy for IPF Upon Lung Transplant Outcomes

Leukemia SPORE Phase II DAC Study for R/R and Elderly Acute AML and MDS

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Study of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL)

Tolerability and Safety of IGI, 10% With rHuPH20 in PIDD

Tolerability and Safety of Immune Globulin Subcutaneous Solution (IGSC) and rHuPH20 in PID

Gammagard Liquid and rHuPH20 in PID

Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Refractory Chronic Cough

Partial Breast Irradiation Using Non Invasive Approach for Early Stage Breast Cancer

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Pivotal Study (Pharmacokinetics, Efficacy, Safety) of BAX 326 (rFIX) in Hemophilia B Patients

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