Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins University
This is a randomized blinded Phase I clinical trial. Thirty patients total will be randomized on a 2:1 basis to treatment (IV Diazoxide added to cardioplegia) vs control (cardioplegia alone). Diazoxide will be added to the first dose of cardioplegia only. Subsequent doses of cardioplegia will not contain additives.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18 years or older
Scheduled for cardiac surgery with cardiopulmonary bypass and cardioplegic arrest
Patient scheduled for elective cardiac surgery
You may not be if
Patient with Diabetes Mellitus on sulfonylurea medications
Scheduled for left ventricular assist device (LVAD) or heart transplant
Left ventricular ejection fraction \< 30%
Pre-operative placement or planned use of mechanical circulatory support during surgery
Allergy to Thiazide and its derivatives
History of gout
Patient is pregnant or breastfeeding
Clareo Health | Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
